血清总胆汁酸检测在妊娠期肝内胆汁淤积症中的临床应用价值

The clinical application significance of serum total bile acid detection in intrahepatic cholestasis of pregnancy

妊娠期肝内胆汁淤积症(ICP)常可致妊娠不良结局的风险增高,是围产儿病死率升高的主因之一,可严重影响围生儿的预后,因此应早期诊断、积极治疗,降低ICP致围生儿并发症的发病率及围生儿病死率。血清总胆汁酸(s TBA)是早期诊断ICP的灵敏指标之一。文章从s TBA与ICP的关系、s TBA和肝功能指标对ICP的应用价值、s TBA对胎儿的影响及ICP的发病机制方面对s TBA在ICP中的作用和临床应用价值进行了综述。

Intrahepatic cholestasis of pregnancy（ICP） can increase the risk of adverse pregnancy outcome, and can seriously affect the prognosis of perinatal infants, and it is one of the main perinatal mortality factors.ICP should be early diagnosed and aggressively treated to reduce perinatal morbidity and mortality.Serum total bile acid （sTBA） is a sensitive index for the early diagnosis and treatment of ICP.This paper reviews the relationship of sTBA with ICP and sTBA with liver function indices, the application significance for ICP, the influence of sTBA on fetus and the pathogenesis of ICP, and reviews the role of sTBA in ICP and its clinical application significance.