轮状病毒感染机制新进展

Progresses of the pathogenesis of rotavirus infection

轮状病毒（rotavirus,RV）是世界范围内引起婴幼儿重症腹泻的最主要病原,而对于RV腹泻至今尚无特效治疗药物.目前对于RV感染的致病机制有多种说法,但尚无确切结论.在RV感染过程中,RV病原体必须克服宿主抗病毒先天免疫反应才能在宿主细胞中成功复制,而在此过程中RV编码的蛋白起到了重要作用.该文对RV编码蛋白在RV感染机制中的作用的研究进展加以综述.

Rotavirus is the most important pathogen causing severe diarrhea in infants and young children worldwide,and for rotavirus diarrhea there is no specific treatment so far.At present,there are a variety of claims on the pathogenesis of rotavirus infection,but none is conclusive.In the process of infection,rotavirus pathogens must overcome antiviral innate immune response that can replicate in host cell.Rotavirus encoded proteins play an important role in the process of rotavirus infection.This paperreviews the role of rotavirus encoding proteins in the pathogenesis of rotavirus infection.