C反应蛋白在新生儿败血症中的诊断价值研究

Research on the value of C reactive protein in diagnosis of neonatal septicemia

目的研究C反应蛋白(CRP)在新生儿败血症诊断中的诊断价值。方法选取60例被确诊为败血症的新生儿设为观察组,同时选取60例健康新生儿设为对照组。测定血清CRP水平并同时检测白细胞(WBC)计数,进行血培养,对血培养阳性的患儿进行药敏实验。比较CRP、WBC、CRP+WBC的诊断价值。结果观察组中,血培养阳性54例,CRP阳性49例,WBC阳性38例。CRP+WBC检测新生儿败血症的准确率明显高于CRP和WBC单独检测(P<0.05)。CRP+WBC联合检测的ROC曲线下面积为0.852 1,高于CRP和WBC。结论 CRP联合WBC检测对于诊断新生儿败血症具有一定的临床应用价值。

Objective To study the value of C reactive protein （CRP） in the diagnosis of neonatal septicemia .Methods 60 cases of neonatal septicemia were selected as observation group ,at the same time ,60 cases of healthy newborns were selected as control group .The levels of CRP and WBC were detected ,and the blood culture was accessed .Drug sensitive test was progressed in infants with positive blood culture results .The diagnostic values of CRP ,WBC and CRP＋ WBC were compared .Results In observation group ,there were 54 cases ,49 cases and 38 cases with positive results of blood culture and the detections of CRP and WBC ,respec‐tively .The accuracy of CRP＋WBC was significantly higher than separate detections of CRP and WBC （P〈0 .05） .The ROC AUC of CRP＋WBC was 0 .852 1 ,which was higher than that of CRP and WBC .Conclusion CRP combined with WBC detection has certain clinical application value in diagnosis of neonatal septicemia .