急性脑梗死患者血清IL-1β、IL-8及TNF-α的临床意义

Clinical significance of IL-1β,IL-8 and TNF-αexpression in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平的变化及其临床意义。方法用酶联免疫吸附测定(ELISA)检测187例急性脑梗死患者血清IL-1β、IL-8及TNF-α的水平,并与150例健康者进行比较。结果急性脑梗死患者不同梗死体积亚组血清IL-1β、IL-8及TNF-α水平均高于对照组,差异均有统计学意义(P<0.05),并且随梗死体积的增加而增高。结论急性脑梗死患者血清IL-1β、IL-8及TNF-α水平增高,其升高的程度与梗死体积密切相关,可用于其病情评估、疗效监测和预后判断。

Objective To explore the changes and clinical significance of the serum concentrations of serum IL‐1β,IL‐8 and TNF‐αin patients with acute cerebral infarction .Methods Serum concentrations of IL‐1β,IL‐8 and TNF‐αfrom 187 patients with acute cerebral infarction and 150 healthy donors were determined by enzyme linked immunosorbent assay （ELISA） .Results The serum levels of IL‐1β,IL‐8 and TNF‐αwere markedly higher in the 3 different infarct size subgroups than in the control group ,and the 3 indexes were statistically increased with increasing infarct size .Conclusion Serum levels of IL‐1β,IL‐8 and TNF‐αincreased markedly in patients with acute cerebral infarction ,which was closely related to infarct size ,and could be used as the indicators for severity assessment ,therapy monitoring and prognosis judgement in acute cerebral infarction patients .