人成纤维细胞生长因子21研究进展
摘要
人成纤维细胞生长因子21（FGF21）是参与代谢调节的一种蛋白质，因为能纠正多种代谢异常，被认为是一种潜在的治疗代谢性疾病的新药。近来关于其作用机制的研究取得了显著进展。然而，FGF21调节代谢异常的确切机制仍不明确。本文就FGF21的作用、药理机制、分子学特征等研究进展综述如下。
出处
《国际检验医学杂志》
CAS
2015年第10期1428-1430,共3页
International Journal of Laboratory Medicine
参考文献18
-
1Kharitonenkov A,Shanafelt AB. FGF21:a novel prospect for the treatment of metabolic diseases[J]. Curr Opin Investig Drugs, 2009,10(4) :359-364.
-
2Eto K, Tumenbayar B, Nagashima S, et al. Distinct association of serum FGF21 or adiponectin levels with clinical parameters in pa-tients with type 2 diabetes[J]. Diabetes Res Clin Pract, 2010,89 (1) : 52-57.
-
3Flier JS. Hormone resistance in diabetes and obesity:insulin, Lep- tin,and FGF21[J]. Yale J Biol Med,2012,85(3) :405-406.
-
4Kamimura N, Nishimaki K,Ohsawa I, et al. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 anti stimulating energy metabolism in db/db mice[J]. Obesity, 201] , 19(7) :1396- 1403.
-
5Li X, Fan X, Ren F, et al. Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver dis- ease and associated with hsCRP levels independently[J]. Diabetes Res Clin Pract,2011,93(1) :10-16.
-
6Gaich G, Chien JY, Fu H, et al. The effects of LY2405319, an FGF21 analog,in obese human subjects with type 2 diabetes[J]. Cell Metabolism, 2013,18(3) : 333-340.
-
7Veniant MM, Komorowski R, Chen P, et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhe sus monkeys[J]. Endocrinology, 2012,153(9) : 4192-4203.
-
8Zhang M, Liu Y, Xiong Z, et al. Changes of plasma fibroblast growth factor-21 (FGF-21) in oral glucose tolerance test and effects of metformin on FGF 21 levels in type 2 diabetes mellitus [J]. Endokrynologia Polska, 2013,64 (3):220-224.
-
9Matuszek B, Lenart-Lipinska M,Duma D,et al. Evaluation of con- centrations of FC-F-21 a new adipoeytokine in type 2 diabetes[J]. Endokrynologia Polska, 2010,61 (1) : 50-54.
-
10Mraz M,Bartlova M, Lacinova Z, et al. Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor - 21 in patients with type 2 diabetes and obesity[J]. Clin Endocrinol, 2009,71(3) :369-375.
-
1杨朝晖 ,甘华 .结缔组织生长因子和醛固酮的相互作用在肾脏疾病中的意义[J].现代医药卫生,2004,20(5):323-324.
-
2刘芬兰,闻杰,柏树令,李吉.皮瓣移植前后FGF受体分布特点[J].沈阳医学院学报,2002,4(2):67-70.
-
3林龙英,何永.重症急性胰腺炎代谢调节的治疗探索[J].华西医学,2006,21(2):245-246.
-
4环球要刊巡览[J].中国心血管杂志,2014,19(1).
-
5赵建文,刘芬兰,白富春.Wistar大鼠皮瓣移植前后FGF受体分布变化[J].中国实验动物学杂志,2002,12(5):266-268.
-
6刘军,李维勤.β受体阻滞剂在脓毒症中的作用研究进展[J].肠外与肠内营养,2014,21(4):244-246. 被引量：3
-
7娄彦亭,梁朝朝.泌尿系结石与代谢异常[J].临床泌尿外科杂志,2010,25(8):637-640. 被引量：7
-
8刘芬兰,赵建文,闻杰,刘远峰,柏树令,李吉.FGF受体在皮瓣移植中的分布变化[J].解剖学报,2002,33(6):642-646. 被引量：2
-
9张淼,杜敏联.感染对leptin及胰岛素样生长因子Ⅰ的影响[J].国外医学（儿科学分册）,2001,28(1):48-50. 被引量：2
-
10覃凤均,孙永华.生长激素在烧伤病人中的应用[J].中华整形烧伤外科杂志,1999,15(5):380-382. 被引量：9
