不同年份性病门诊患者支原体感染及药敏分析

Analysis of mycoplasma infection status and drug sensitivity in STD outpatients in different years

目的：了解我院性病门诊患者支原体感染及药物敏感状况。方法：应用Uu、Mh药敏试剂盒,对2009年1008例患者和2014年1753例患者进行支原体培养和药敏试验,观察支原体对13种抗菌药物的敏感和耐药变化。结果：2009年支原体感染的阳性率为22.82%,2014年支原体阳性率为26.87%,2014年支原体感染总阳性率较2009年升高（P〈0.05）。2009年和2014年女性患者支原体总感染率（27.50%）高于男性（22.57%）,差异具有统计学意义（P〈0.01）。支原体阳性患者集中在20-49岁年龄段,阳性者均对强力霉素、美满霉素、交沙霉素敏感率较高,2014年Uu、Mh及Uu、Mh合并感染对大部分药物的敏感率较2009年下降,而耐药率上升。结论：2014年支原体阳性率明显高于2009年,2014年大部分药物耐药率较2009年上升,敏感性较高的药物为美满霉素、强力霉素、交沙霉素,临床治疗应尽可能根据药敏试验选用抗生素。

Objective： To investigate the mycoplasma infection status and drug sensitivity test results in outpatients with sexually transmitted disease（ STD）. Methods： Ureaplasma urealyticum（ Uu） and mycoplasma hominis（ Mh） kit were used to culture mycoplasma,and drug sensitivity test was performed in 1 008 STD patients of 2009 and 1 753 STD patients of 2014 undergone diagnosis and treatment on our outpatient basis in our hospital. Mycoplasma sensibility and resistance changes were observed in 13 sorts of antibacterial drugs. Results： The positive rate of mycoplasma infection was 22. 82% in2009 and 26. 87% in 2014,which showed a rise trend,and female patients had higher total positive rate of mycoplasma infection than males（ 27. 50% vs.22. 57%）. The difference was significant（ P 〈0. 01）. The patients for positive mycoplasma were primarily fallen in age of 20 to 49 years,and better sensitive to doxycycline,minocycline and josamycin. Infection with either Uu or Mh or associated infection with Uu and Mh showed lower sensitivity to most drugs in 2014 than in 2009,which indicated ascended drug resistance. Conclusion： In 2009 and 2014,positive mycoplasma rate and its drug resistance tend to climb in our outpatients,and minocycline,doxycycline and josamycin may produce better sensitivity. Antibiotic use should be based the results of drug sensitivity.