黛力新和阿米替林对老年脑卒中后抑郁的疗效比较

Efficacy Comparison Between Deanxit and Amitriptyline Treating Elderly Post-stroke Depression

目的：比较黛力新和阿米替林治疗老年脑卒中后抑郁的疗效。方法：58例患者随机分为黛力新组和阿米替林组，基于常规脑卒中治疗外分别口服黛力新及盐酸阿米替林，6周后比较两组汉密尔顿抑郁量表（HAMD）评分、综合疗效及不良反应。结果：治疗后两组患者HAMD评分均低于治疗前（P〈0.05），且黛力新组显著低于阿米替林组（P〈0.05）；黛力新组总有效率为86.2%，显著高于对照组的55.2%（P=0.02707〈0.05）；黛力新组不良反应率显著低于阿米替林组（P〈0.05）。结论：黛力新治疗老年脑卒中后抑郁的疗效优于阿米替林，且不良反应少，值得临床推广应用。

Objective：To compare the efficacy between deanxit and amitriptyline treating elderly post-stroke depression. Methods：58 patients were randomly divided into deanxit group and amitriptyline group, based on the conventional stroke treatment respectively with oral deanxit and amitripty-line hydrochloride, to compare the Hamilton Depression Scale （HAMD） score, comprehensive effect and side effect after 6 weeks of two groups. Re-sults：The HAMD scores of two groups after treatment were both lower than those before treatment （P〈0.05）, and deanxit group markedly lower than amitriptyline group （P〈0.05）; the total effective rate of deanxit group was 86.2%, significantly higher than that of control group by 55.2% （P=0.02707〈0.05）;adverse reaction rate of deanxit group was lower than that of amitriptyline group （P〈0.05）. Conclusion：Curative effect of deanxit treating elderly post-stroke depression is better than that of amitriptyline, with less adverse reactions, being worthy of clinical application.