铝碳酸镁联合多潘立酮治疗胆汁反流性胃炎的疗效观察

Efficacy hydrotalcid joint domperidone treatment of bile reflux gastritis

目的:观察铝碳酸镁联合多潘立酮治疗胆汁反流性胃炎的临床疗效。方法:142例胆汁反流性胃炎患者,随机分为两组各71例,对照组给予多潘立酮治疗,观察组在对照组的基础上加用铝碳酸镁联合治疗,比较两组临床疗效。结果:观察组与对照组的有效率分别为95.77%、76.06%,差异显著(X2=11.41,P<0.01)。疗程结束后,观察组临床症状上腹痛、恶心、腹胀积分优于对照组,差异有统计学意义(P<0.01)。观察组24h胆汁监测最长反流时间、反流总时间、反流大于5min次数均优于对照组,差异显著(P<0.05)。结论:铝碳酸镁联合多潘立酮治疗胆汁反流性胃炎,两者联用具有协同作用,比单用多潘立酮的治疗效果显著,值得临床推广。

Objective To investigate the joint domperidone hydrotalcid clinical efficacy of bile reflux gastritis treatment. Methods 142 cases of bile reflux gastritis patients were randomly divided into two groups, each of 71 cases in the control group were treated with domperidone treatment, observation group aluminum magnesium combination therapy on the basis of the control group, the clinical efficacy of two groups were compared. Results of the observation group and the control group response rate was 95.77%, respectively, 76.06%, compare the two groups was significant difference （X^2 = 11.41, P〈0.01）. After treatment, the clinical course of abdominal symptoms in patients treated, nausea, bloating integration than the control group, the difference was statistically significant （P〈0.01）. Treated 24 h bile reflux monitoring the longest time, the total time of reflux, regurgitation greater than 5min times than the control group difference was significant statistically significant. Conclusion hydrotalcid joint domperidone treatment bile reflux gastritis, both combined with a synergistic effect, than the single use of domperidone treatment effect is more significant, worthy of clinical application.