阿司匹林联合辛伐他汀防治缺血性脑血管病临床研究

Clinical studies of ischemic cerebrovascular disease prevention with aspirin and simvastatin

目的：探讨缺血性脑血管病应用阿司匹林联合辛伐他汀治疗的效果,以丰富临床治疗经验。方法：选择2012年6月-2013年6月在我院接收并确诊的缺血性脑血管病患者100例,根据入院治疗顺序随机分为对照组与观察组各50例,对照组通过给予阿司匹林进行治疗,观察组则通过给予阿司匹林以及辛伐他汀同时治疗,治疗后8周,统计两组患者的治疗总有效率,将结果进行对比。一年以后对所有患者进行随访,了解患者的长期病情。结果：治疗后,患者的临床症状均有明显的改善与缓解,观察组治疗的总有效率为84.00%,优于对照组的68.00%,差异显著（P〈0.05）;在治疗一年后,对患者进行随访,观察组心肌梗死、短暂性脑缺血发作以及再发性脑梗死等疾病的发生率为16.00%,远远低于对照组的36.00%,差异显著（P〈0.05）。结论：缺血性脑血管病应用阿司匹林联合辛伐他汀治疗,具有疗效确切、安全可靠等优点,值得临床推广。

Objective： To investigate the use of aspirin in ischemic cerebrovascular disease combined effect of simvastatin to treat clinical experience. Methods：100 patients in June 2012 June 2013 in our hospital received and diagnosed with ischemic cerebrovascular disease were randomly divided into observation group and control group according to the order of hospitalization, 50 patients in the control group by giving aspirin treatment, observation group were given aspirin and simvastatin by simultaneous treatment, after eight weeks of treatment, the statistical treatment of the two groups of patients with total efficiency, the results were compared. After a year and a random visit to investigate all patients understand the long-term status of the patient＇s condition. Results： After treatment, clinical symptoms were significantly improved and mitigation, treatment observation group total effective rate 84.00%, 68.00% better than the control group, the difference was significant （P〈0.05）; in the treatment of a year after patients were randomized to visit, observe myocardial infarction, transient ischemic attack, and the incidence of recurrent infarction and other diseases is far below the 36.00%16.00% in the control group, the difference was significant （P〈0.05）. Conclusion： ischemic cerebrovascular disease with aspirin and simvastatin treatment has efficacy, safe, etc., should be promoted in the clinical treatment.