(R)-3-氨基哌啶双盐酸盐的合成工艺研究

Study on the synthesis and technology of( R)-3-aminopiperidine dihydrochloride

以外消旋的3-哌啶甲酸乙酯为原料,经手性拆分,胺基Boc保护,胺解,Hofman降解,脱保护成盐酸盐共五步反应制得R-3-氨基哌啶双盐酸盐,所得目标化合物经质谱、核磁共振氢谱确认,总收率达43.1%。

（ R）-3-aminopiperidine dihydrochloride was synthesized from Ethyl nipecotate,by chiral separation,Boc protection,amin-olysis,Hofmann rearrangement,deprotection into hydrochloride The target compound was identified by MS and 1 H-NMR,and the o-verall yield was 43. 1%.