BCR信号途径在B细胞肿瘤中的作用及靶向药物研究

Inhibitors of B-cell receptor signaling in B-cell lymphoma

B细胞受体（BCR）复合物及其介导的下游信号途径在正常B细胞及多种B细胞肿瘤中发挥着着至关重要的作用,调控BCR途径关键分子的活性可以选择性地促进或抑制特定B细胞扩增。近年来,针对此通路上不同成分的靶向药物在B细胞肿瘤的临床试验中取得良好的治疗效果,如脾酪氨酸激酶（Syk）抑制剂、PI3K抑制剂、Bruton＇s酪氨酸激酶（Btk）抑制剂等。

Summary The B-cell receptor （BCR） complex and its down-stream pathway play a critical role in the devel- opment, proliferation, and survival of normal or malignant B cells. Regulated activity of the BCR complex promotes the expansion of selected B cells and the deletion of unwanted ones. Compounds that inhibit various components of this pathway, including spleen tyrosine kinase （Syk） ,Bruton＇s tyrosine kinase （Btk）, and phosphoinositol-3 kinase （PI3K）, have been developed. Herein we summarize the agents that can inhibit BCR-signaling to treat patients with either indolent or aggressive B-cell lymphomas.