糠酸莫米松鼻喷雾剂联合孟鲁司特钠治疗变应性鼻炎临床效果观察

Effect of mometasone furoate nasal sprays combined with montelukast on allergic rhinitis

目的对比观察单独使用糠酸莫米松鼻喷雾剂与联合孟鲁司特钠治疗变应性鼻炎(AR)的临床疗效。方法将100例AR患者随机分为观察组和对照组。在鼻腔冲洗的基础上,观察组患者予糠酸莫米松鼻喷剂联合孟鲁司特片治疗,对照组患者仅予糠酸莫米松鼻喷剂治疗,两组疗程均为12 w。观察两组变应原分布情况并比较两组临床疗效。结果变应原分布前3位为野草类、树木类、寄生虫类。随着治疗时间的延长,观察组与对照组鼻痒、鼻塞、流涕、喷嚏症状评分及鼻内镜下体征评分均有下降,且观察组下降速度较对照组明显,两组差异均有统计学意义(P<0.05)。结论糠酸莫米松鼻喷剂联合孟鲁司特治疗AR疗效优于单用糠酸莫米松治疗。

Objective To observe and compare the curative effect of mometasone furoate nasal sprays alone and combined with montelukast on allergic rhinitis （AR）. Methods Totally 100 cases of patients with AR were divided into the observation group and the control group at random. Based on nasal wash, the patients in the observation group were given mometasone furoate nasal sprays combined with montelukast, while the patients in the control group were only given mometasone furoate nasal sprays for 12 weeks. The distribution of allergens and clinical curative effect in the two groups were observed and compared. Results Top three of allergen distribution were grass, trees and parasitic worms. Symptom scores （nasal itching, nasal congestion, runny nose, sneezing） and nasal endoscopic signs scores were both decreased in observation group and control group, The scores of observation group declined more significantly than the control group, Differences between the two groups have statistical significance （P 〈0.05）. Conclusion Compared with mometasone furoate nasal sprays. The curative effect of mometasone furoate nasal sprays combined with montelukast in the treatment of AR is better.