血液灌流对尿毒症患者微炎症状态和动脉粥样硬化的影响

Influence of hemoperfusion on microinflammatory state and atherosclerosis in uremic patients

目的观察血液灌流(HP)对尿毒症患者微炎症状态和动脉粥样硬化的影响。方法将36例尿毒症患者分为2组,每组18例,血液透析(HD)组每周透析3次,4h/次;HP+HD组在HD的基础上,每周1次HP。治疗6个月后,检测治疗前后血C反应蛋白(CRP)、总胆固醇(TC)、三酰甘油(TG)、血尿素氮(BUN)、血肌酐(Cr)的水平,超声测定颈动脉粥样斑块大小。结果与治疗前及HD组治疗后比较,HP+HD组治疗6个月后CRP、TG和TC显著下降(P<0.05),粥样斑块发生例数无增加。BUN、Cr两组差异无统计学意义(P>0.05)。结论 HP可减轻炎性反应,减少动脉粥样硬化的发生。

Objective To observe the influence of hemoperfusion（HP） on microinflammatory state and atherosclerosis in uremic patients. Methods Thirty-six patients with uremia were randomly assigned into 2 groups,18 cases in eath group. The hemo-dialysis（HD） group took hemodialysis for 3 times per week,4 h per time,the HP＋HD group took once HP per week on the basis of HD. The levels of C-reactive protein（CRP） ,total cholesterol（TC）, triglyceride（TG）, urea nitrogen（BUN） and serum creatinine （Cr） were measured before therapy and in six months after therapy. The atherosclerotic plaque size was detected by ultrasound with fine resolution. Results The levels of CRP, TG and TC after treatment in the HP＋ HD group were significantly decreased compared with those before treatment and the HD group （P〈0, 05）. The number of therosclerotic plaques in the HP＋HD group had no increase. BUN and Cr had no statistical differences between the two groups（P〉0.05）. Conclusion HP can alleviate the inflammatory reaction and decrease the atherosclerosis occurrence.