TNF-α在妊娠期肝内胆汁淤积症中表达的研究

Research on expression of TNF-αin intrahepatic cholestasis of pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)患者总胆汁酸(TBA)、甘胆酸(CG)、肝生化指标、肿瘤坏死因子-α(TNF-α)对产妇和围生儿的影响。方法对2012年1月至2013年12月收治的164例ICP患者的临床资料进行回顾性分析,放射免疫法分析TBA、CG、TNF-α,生化仪分析肝功能。结果 ICP患者较健康产妇的TBA、CG、总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)均有增加,即肝功能受到损伤,血清TNF-α表达增加,重度ICP患者较轻度ICP患者上述指标升高,产后出血率增加,Apgar评分降低(P<0.05)。结论 ICP系高危妊娠,TNF-α和CG、TBA共同反映ICP的病情严重程度。

Objective To investigate the influence of total bile acid （TBA） ,cholyglycine（CG） ,biochemical parameters of liver,tumor necrosis factor-α（TNF-α） in the patients of intrahepatic cholestasis of pregnancy （ICP） on parturients and perinatal newborns. Methods The clinical data in 164 cases of ICP in our hospital from January 2012 to December 2013 were retrospectively analyzed. TBA, CG and TNF-α were detected by the radioimmunoassay and TBIL, DBIL, ALT and AST were analyzed by the biochemical analyzer. Results TBA, CG, TBIL, DBIL and ALT in the patients with ICP were increased than those in normal pregnant women,i, e. the liver function was damaged,serum TNF-α expression was increased,the above indexes in the patients with severe ICP were increased compared with the mild ICP patients,postpartum hemorrhage volume was increased and the Apgar scores were decreased （P〈0.05）. Conclusion ICP is high risk pregnancy. TNF-α,CG and TBA reflect the severity degree of ICP.