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Vaspin与代谢综合征的研究进展 被引量:3

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摘要 大量研究表明,脂肪组织不但是机体主要的能量储存组织,而且作为机体重要的内分泌组织,分泌众多生物活性物质(脂肪细胞因子),如瘦素、脂联素、抵抗素、炎症因子、纤溶酶原激活物抑制因子-1及各种生长因子等[1-2]。脂肪细胞因子在机体肾脏、免疫、内分泌及神经系统等各系统发挥着重要的病理生理作用[3]。
出处 《重庆医学》 CAS 北大核心 2015年第14期1991-1993,共3页 Chongqing medicine
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  • 1Bray GA. Medical Consequences of obesity[J]. J Clin En- docrinol Metab,2004,89(6) :2583-2589.
  • 2Ahima RS, Osei SY. Adipokines in ohesity[J]. Front Horm Res,2008,36(7) ..182-197.
  • 3Van Gaal LF, Mertens IL,De Block CE. Mechanisms link- ing obesity with cardiovascular disease[J]. Nature, 2006, 444(7121) .. 875-880.
  • 4Hida K, Wada J, Eguchi J, et al. Visceral adipose tissue- derived serine protease inhibitor:A unique insulin-sensiti- zing adipocytokine in obesity[J]. Proc Natl Acad Sci U S A, 2005,102 (30) : 10610-10615.
  • 5Li HL, Peng WH, Zhuang JH, et ah Vaspin attenuates high glucose-induced vascular smooth muscle cells proli[ eration and chemokinesis by inhibiting the MAPK,PI3K/ Akt,and NF-kappa B signaling pathways[J]. Atheroscle- rosis, 2013,228(1) :61-68.
  • 6Kloting N, Kovacs P, Kern M, et al. Central vaspin admin-istra-tion acutely reduces food intake and has sustained blood glucose-lowering effects [J ]. Diabetotogia, 2011,54 (57) :1819-1823.
  • 7Kloting N, Berndt J, Kralisch S, et al. Vaspin gene expres- sion in human adipose tissue : Association with obesity and type 2 diabetes[J]. Biochem Biophys Res Commun,2006, 339(1) :430-436.
  • 8Zvonic S, Lefevre M, Kilroy G, et al. Secretome of primary cultures of human adipose-derived stem cells [J]. Mol Cell Proteomics,2007,6(1) : 18-28.
  • 9Tan BK, Heutling D, Chen J, et al. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance[J]. Diabe- tes, 2008,57 (6) : 1501-1507.
  • 10Koerner A,Neef M,Friebe D,et al. Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children[J]. Int J Obes, 2011,35 (4) : 578-586.

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