氯吡格雷对急性冠脉综合征患者血小板聚集功能影响的实验室观察

Laboratory observation on influence of clopidogrel on platelet aggregation function in patients with acute coronary syndrome

目的研究138例急性冠脉综合征患者服用氯吡格雷对血小板聚集功能的影响。方法利用血小板聚集测试仪、流式细胞仪测定服用氯吡格雷前和服用7d后患者二磷酸腺苷(ADP)诱导的血小板聚集率、P选择素、活化GPⅡb/Ⅲa的变化。结果连续服用氯吡格雷7d后,血小板聚集率明显减少(P<0.01);血小板表面表达的P选择素、活化GPⅡb/Ⅲa明显减少(P<0.01)。结论急性冠脉综合征患者在服用氯吡格雷治疗后能显著降低血小板聚集,起到抵抗血小板聚集的效果。

Objective To study the effects of taking clopidogrel on relevant indicators of platelet aggregation function in 138 cases acute coronary syndrome （ACS） .Methods The platelet function analyzer and flow cytometry were adopted to detect the ADP‐induced platelet aggregation rate ,P selectin and activated GP Ⅱ b/ Ⅲ before medication and on 7 d after taking clopidogrel . Results The platelet aggregation rate after taking clopidogrel for 7 continuous d was decreased significantly （P〈0 .01）;the P se‐lectin level and activated GP Ⅱ b/ Ⅲ a expressed on platelet surface were significantly reduced （P〈0 .01） as well .Conclusion Taking clopidogrel could reduce the platelet aggregation significantly in the patients with ACS and has the effect for inhibiting the platelet aggregation .