新疆哈萨克族、汉族血浆非对称二甲基精氨酸水平与原发性高血压的相关性研究

Correlation between plasma asymmetric dimethylarginine and essential hypertension of Kazak and Han nationalities in Xinjiang

目的探讨血浆非对称二甲基精氨酸(ADMA)与原发性高血压的相关性。方法选择哈萨克族原发性高血压患者(n=93)及汉族患者(n=112),以哈萨克族(n=81)及汉族(n=100)健康人作为健康对照组,采用反相高效液相色潽法(RPHPLC)法分别检测两个民族原发性高血压患者及健康对照组人群血浆中ADMA水平,同时检测肝、肾功能,血脂、血糖、果糖胺等生化指标。结果两个民族原发性高血压患者血浆ADMA水平较健康人群显著升高(P<0.01),血浆ADMA水平与高血压患者血压水平呈正相关(哈萨克族r=0.715,P<0.01;汉族r=0.645,P<0.01)。结论新疆哈萨克及汉族血浆ADMA水平与原发性高血压之间均具有相关性,提示ADMA可能参与了原发性高血压的发生及发展。

Objective To explore the correlation between plasma asymmetric dimethylarginin（ADMA） and essential hyper‐tention（EH） by comparing the difference of plasma asymmetric dimethylarginine levels between Kazak and Han patients with EH in Xinjiang .Methods 91 Kazak and 112 Han patients with EH were selected .81 Kazak and 110 Han healthy people were selected as healthy control groups .The plasma ADMA levels in EH groups and the control groups were measured by using the reverse phase‐high performance liquid chromatography （RP‐HPLC） .Meanwhile the liver function ,renal function ,blood lipids ,blood glucose and fructosamine were measured .Results Kazak and Han patients with EH had higher levels of plasma ADMA than the control groups （P〈0 .01）;there was a positive correlation between the plasma ADMA and blood pressure levels of EH patients in two na‐tionalities（r=0 .715 ,P〈0 .01 for Kazak ;r=0 .645 ,P〈0 .01 for Han） .Conclusion Both Kazak and Han patients with EH have higher levels of ADMA than the respective healthy control group in Xinjiang .The correlation between the plasma levels of ADMA and EH existed ,which indicate that ADMA might be involved in the occurrence and development of EH .