In对S-TiO_2纳米材料的吸附与缓释特性的调控

Regulation of Indium on the Adsorption and Release Characteristics of S-TiO_2 Nanomaterial

以固相反应法所合成的铟、硫掺杂二氧化钛纳米粉体为载体,研究了三磷酸腺苷(ATP)的吸附与缓释行为。结果表明,以TiO2为基体的纳米材料对ATP都有良好的吸附作用。40 min内,Inx-S-TiO2(x=0.01,0.02,0.03,0.04,0.05)、STiO2和TiO2纳米粉体对ATP的吸附率(%)依次为82.3、91.5、98.6、93.7、89.2、75.7和66.0。其中In0.03-S-TiO2纳米粉体的载药量比纯TiO2提高了32.6%。In的含量与其吸附ATP的量呈抛物线型。纯TiO2及In、S改性纳米材料对ATP的释放均有一定的调控作用。5.5 h内,其释药百分比分别为In0.01-S-TiO2(61.4%)>In0.05-S-TiO2(59.23%)>In0.02-S-TiO2(57.9%)>In0.04-S-TiO2(55.30%)>In0.03-S-TiO2(51.45%)>TiO2(37.5%)>S-TiO2(25.8%)。In的掺杂,对S-TiO2纳米材料缓释ATP的速率起到明显缓释控制作用。ATP的缓释过程符合骨架溶蚀扩散机理。In在ATP释放过程中的流失量很少,均不足2%。In含量的变化对微球的突释效应有一定的调控作用。

The adsorption and release behavior of adenosine triphosphate （ATP） were investigated on the surface of indium, sulfur doped titanium dioxide nanomaterials prepared by solid-state reaction method. The results showed that, the favorable adsorption properties of ATP on these nanomaterials were presented. Within 40 min, the adsorption ratio of ATP was 82. 3% , 91.5% , 98. 6% , 93.7%, 89. 2% , 75.7% and 66. 0% corresponding for In0.01 -S-TiO2, In0.02-S-TiO2, In0.03-S-TiO2, In0.04-S-TiO2, In005-S-TiO2, S-TiO2 and pure TiO：, respectively. Thereinto, the drug capacity of ATP was improved 32. 6% on the In0.03-S-TiO2 nanomaterial rather than pure TiO2. And it was parabola between the content of indium and the adsorption amount of ATP in the Inx - S - TiO2 （ x = 0. 01, 0. 02, 0. 03, 0. 04, 0. 05 ） nanomaterials. Simultaneity, the release of ATP is controlled by these nanomaterials. In 5.5 h, the drug delivery percent of ATP was In0.01 -S-TiO2（61.4% ） 〉 In0.05 -S-TiO2 （59.23%） 〉 In0.02 -S-TiO2 （57.9%） 〉 In0.04 - S-TiO2 （55.30%） 〉 In0.03 - S-TiO2 （51.45%） 〉TiO2（37.5% ）〉S-TiO2（25.8% ） corresponding sequence in turn. Evidencely, the release rate of ATP on the S-TiO2 nanomaterial surfaces was sustained by the doping of indium. Moreover, the release process of ATP on these nanomaterial surfaces meets the skeleton solution diffusion mechanism and the maxium leaching ratio of indium was less than 2%. The burst release effect of mierosphere nanomaterials was affected by the change of indium content.