摘要
目的:探讨非瓣膜性心房颤动(房颤)患者尿酸(UA)与评估房颤患者血栓栓塞风险的CHADS2、CHA2DS2-VASc评分的关系。方法:连续入选非瓣膜性房颤188例,对患者进行CHADS2和CHA2DS2-VASc评分,同时记录年龄、性别、伴发疾病、实验室指标、超声心动图结果等。根据CHADS2、CHA2DS2-VASc评分将房颤发生血栓栓塞的风险分为低中危和高危组,比较房颤患者发生血栓风险低中危组与高危组各项指标的差异,同时探讨房颤患者UA与CHADS2和CHA2DS2-VASc评分之间的关系。结果:无论何种分组方式,两组间年龄、高血压史、糖尿病史、冠心病史、脑卒中有统计学差异(P<0.05),与低中危组相比,高危组年龄增加,UA、左房内径(LAD)、左室舒张末内径(LVEDD)增加(P<0.05),左室射血分数(LVEF)下降(P<0.05)。相关分析显示,尿酸、LAD、LVEDD和CHADS2、CHA2DS2-VADSc评分呈正相关,LVEF和CHADS2、CHA2DS2-VADSc评分呈负相关。结论:非瓣膜性房颤患者UA与CHADS2、CHA2DS2-VASc评分呈正相关。
O bjective：To investigate the relationship between uric acid（UA） and CHADS2,CHA2DS2-VASc score for the evaluation of thromboembolism risk in patients with nonvalvular atrial fibrillation（AF）. Methods： One hundred and eighty-eight patients with nonvalvular AF（69 with paroxysmal AF and 119 with persistent AF） were collected in this study. The baseline clinical data were detected including age,sex, comorbidties, laboratory parameters and ecocardiography. CHADS2 and CHA2DS2-VASc risk scores for each patient were calculated.According to CHADS2 and CHA2DS2-VASc scores, the AF patients were divided into low-intermediate group and high risk group respectively,and the parameters between the two groups were compared,and the relationship between UA and AF were evaluated.Results： The base characteristics between two groups had significant differences in age and comorbidities,in all groups method. Group with higher CHADS2 and CHA2DS2-VASc scores had older age,higher UA, left atrial diameter（LAD）,left ventricular end-diastolic diameter（LVEDD） and lower left ventricular ejection fraction（LVEF）. The correlation analysis showed UA,LVEDD,LAD and CHADS2,CHA2DS2-VASc score were positively correlated,however LVEF and CHADS2,CHA2DS2-VASc score were negatively correlated.Conclusion： UA is significantly correlated with CHADS2 and CHA2DS2-VASc scores in patients with AF.
出处
《天津医科大学学报》
2015年第3期185-188,共4页
Journal of Tianjin Medical University
