紫癜肾汤治疗儿童紫癜性肾炎早期肾损害的疗效观察

Observation on the curative effect of Purpura kidney decoction in treatment of early renal damage in children with Henoch- Schonlein purpura nephritis

目的：探讨紫癜肾汤治疗儿童紫癜性肾炎的疗效。方法：选取2009年1月～2014年6月在该院住院的紫癜性肾炎（Henoch-Schonlein purpura nephritis,HSPN）患儿100例为研究对象,随机分成观察组和对照组,每组各50例。观察组接受常规西医治疗的基础上加用紫癜肾汤,对照组接受常规西医治疗。结果：观察组总有效率98.00%,高于对照组的总有效率72.00%,差异有统计学意义（P〈0.01）。随访6个月,观察组复发率8.00%,低于对照组的复发率28.00%,差异有统计学意义（P〈0.01）。治疗后,观察组患儿尿Ig G、α1微球蛋白、β2微球蛋白水平、CD4＋/CD8＋水平均低于对照组,差异均有统计学意义（P〈0.05、P〈0.01）。治疗后,观察组患儿CD3＋、CD4＋及CD8＋水平均高于对照组,差异有统计学意义（P〈0.01）。治疗后,观察组患儿血清IL-6、IL-18、TNF-α均低于对照组,差异均有统计学意义（P〈0.01、P〈0.05）。治疗后,观察组患儿血清IL-10高于对照组,差异有统计学意义（P〈0.01）。结论：紫癜肾汤治疗儿童紫癜性肾炎疗效显著,可有效调节患者免疫功能,减轻患者炎症反应,改善肾组织病理损伤。

Objective： To explore the curative effect of Purpura kidney decoction in treatment of early renal damage in children with Henoch-Schonlein purpura nephritis. Methods： One hundred hospitalized children with Henoch-Schonlein purpura nephritis were se- lected from January 2009 to June 2014 and randomly divided into observation group and control group, 50 children in each group. The chil- dren in observation group were treated with Purpura kidney decoction based on conventional western medicine treatment, while the children in control group were treated with conventional western medicine treatment. Results： The total effective rate in observation group was 98.00%, which was statistically significantly higher than that in control group （72.00%） （P〈0. 01 ） . After follow-up for six months, the recurrence rate in observation group was 8.00%, which was statistically significantly lower than that in control group （28.00%） （ P〈0. 01 ） . After treatment, urine IgG, α1 microglobulin, β2 microglobulin, and CIM＋/CD8＋ levels in observation group were statistically significantly lower than those in control group （P〈0. 05, P〈0. 01 ） ; CD3＋, CI4＋, and CD8＋ levels in observation group were statistically significantly higherthan those in control group （P〈O. 01）; serum IL-6, IL-18, and tumor necrosis factor-α （TNF-α） levels in observation group were statistically significantly lower than those in control group （ P〈0. 01,P〈0. 05） ; serum IL- 10 level in observation group was statistically significantly higher than that in control group （ P〈0. 01 ） . Conclusion： The curative effect of Purpura kidney decoction in treatment of children with Henoch-Schonlein purpura nephritis is significant, which can ef- fectively regulate immune function, reduce inflammation, improve pathological lesions of renal tissue of the patients.