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二代杂交捕获技术联合液基细胞学检测在宫颈癌早期筛查中的临床应用 被引量:9

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摘要 目的:探讨二代杂交捕获技术(HC2)联合液基细胞学检测(LCT)在宫颈癌早期筛查中的临床应用。方法:选取2011年2月~2013年10月在该院体检的已婚女性1 260例,应用HC2联合LCT检测HPV高危感染情况及子宫颈细胞学,并对阳性患者采取宫颈组织病理活检。结果:1 260例受检女性中宫颈上皮病变阴性(NILM)836例,未明确诊断的非典型鳞状上皮细胞(ASCUS)162例,低级别宫颈鳞状上皮病变(LSIL)196例,高级别宫颈鳞状上皮病变(HSIL)43例,宫颈鳞状细胞癌(SCC)23例。1 260例受检女性中存在HPV感染493例,单一类型HPV感染412例,双重HPV类型感染50例,3种及其以上HPV类型感染31例。排名前3位的单一HPV感染类型为16、58和18。836例NILM中,HC2阳性260例(31.1%);162例ASCUS中,HC2阳性73例(45.1%);196例LSIL中,HC2阳性116例(59.2%);43例HSIL中,HC2阳性31例(72.1%);23例SCC中,HC2阳性21例(91.3%)。LCT检查对CINⅡ+CINⅢ,宫颈浸润癌的总检出率为74.4%(64/86);HC2检查对CINⅡ+CINⅢ,宫颈浸润癌的总检出率为87.2%(75/86),两者比较,差异有统计学意义(χ2=7.45,P〈0.05)。LCT+HC2联合检查对CINⅡ+CINⅢ,宫颈浸润癌的总检出率为95.3%(82/86),与HC2检出率比较,差异有统计学意义(χ2=6.14,P〈0.05)。结论:在宫颈癌的早期筛查中采用HC2联合LCT检测,可提高检测的阳性率,降低其漏诊率。检测结果为阳性的患者应列为高危群体,及时进行进一步检查以明确诊断,并及早进行治疗。
出处 《中国妇幼保健》 CAS 2015年第16期2672-2674,共3页 Maternal and Child Health Care of China
关键词 HC2 LCT HPV 宫颈癌 筛查
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