脑卒中后抑郁患者早期血清BDNF含量及相关因素研究

Study on the Content of Serum BDNF in Early Stage and Related Factors in Patients with Depression after Acute Stroke

目的探讨脑卒中后抑郁患者早期血清脑源性神经营养因子(BDNF)含量及与神经功能缺损程度、认知功能、日常生活能力的相关性。方法将88例脑卒中患者按照有无抑郁症状分为两组,抑郁患者组(PSD组)33例,无抑郁患者组(非PSD组)55例,在入院两周后检测分析两组患者的血清BDNF含量及评定汉密顿抑郁量表(HAMD)、简易智能筛查量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)和日常生活能力评分(Barthel)指数。结果 88例脑卒中患者中抑郁发生率为37.50%,抑郁程度大多为轻中度,有5例为重度(5.68%)。非PSD患者的BDNF水平,HAMD、MMSE、NIHSS评分及Barthel指数显著高于PSD组,差异有统计学意义(P<0.01);血清BDNF水平与睡眠障碍因子、焦虑/躯体化间存在显著的负相关(r=-0.45,-0.29,P<0.01),与迟滞也具有明显的负相关(r=-0.27,P<0.05)。结论早期检测血清BDNF可作为预测脑卒中后抑郁患者的一个生物学指标。

Objective To investigate the content of serum BDNF in early stage in patients with post-stroke depression,and the correlation between the content and the degree of nervous function defect,cognitive function,daily life ability. Methods88 stroke patients were divided into two groups according to depressive symptoms,patients with post-stroke depression( group PSD,n = 33) and patients without depression group( group NPSD,n = 55). Two weeks after admission,serum BDNF content detection and evaluation of HAMD,MMSE,NIHSS and Barthel index comparative analysis were taken. Results Among88 cases,incidence rate among patients with stroke is 37. 50%,the degree of depression are mostly mild to moderate,there were 5 cases of severe( 5. 68%). NPSD had higher BDNF level,HAMD,MMSE,NIHSS and Barthel index than that of PSD,the difference is statistically significant( P < 0. 01). The level of BDNF in serum and sleep disorders,anxiety / somatization factor has significant negative correlation( r =- 0. 45,- 0. 29,P < 0. 01),and hysteresis also has a significant negative correlation( r =- 0. 27,P < 0. 05). Conclusions Serum BDNF in early stage could serve as a biological indicator for predicting depression in patients after stroke.