中西医结合治疗卵巢早衰48例疗效观察

Curative observation on treatment of 48 cases with premature ovarian failure by integrated Chinese and western medicine

目的观察中西医结合卵巢早衰的临床疗效.方法：48 例患者,给予中药1 剂/d,2 次/d,连服21 d,中间休息7 d,连续3 个疗程.同时口服戊酸雌二醇片1 mg,1 次/d,连服21 d,于服雌激素后第12 d 加用安宫黄体酮,每天6 mg,连服10 d,同时停药.待下次月经来潮第5 d 开始续服上药,进入下1 个周期治疗,连续服用3 个月经周期.治疗前后各测1 次血激素含量：卵泡刺激激 （FSH）黄体生成素（LH）、催乳素（PRL）雌二醇（E2）等.有月经周期者均在周期1～3 d 测定.停药3 个月以后进行观察疗效.结果：痊愈23 例, 显效12 例,有效6 例,无效7 例,总有效率85.4%.结论：中西医结合治疗卵巢早衰的临床疗效显著,值得进一步研究.

ObjectiveTo observe the clinical effects of integrative medicine of premature ovarian failure. Method 48 patients weretreated with traditional Chinese medicine, one dose daily, twice a day, for 21 days. After a 7-day pause, another 21days of the sametreatment continues. At the same time, the patient is treated with oral Estradiol Valerate Tablets 1mg, once a day, for 21 days. On the twelfthday after estrogen, medroxyprogesterone acetate is treated for 10 days, 6mg a day. On the fifth day of the next menstruation another cycleof the same treatment continues,for 3 cycles. Before and after the treatment, blood follicle stimulating hormone content is measured： bowel（FSH） luteinizing hormone （LH）, prolactin （PRL） and estradiol （E2） etc.. The patients with the menstrual cycle are measured in the periodof the first 3 days. 3 months after the treatment curative effect is observed. The results： 23 recovery , 12 good effect, 6 effect, 7 invalid.Thetotal efficiency is 85.4.