丹皮酚及其结构类似物的修饰与抗炎活性研究

Modification and Anti-inflammatory Activity of Paeonol and its Structural Analogues

以丹皮酚及其结构类似物和布洛芬为原料,通过碳二亚胺法或酰氯法合成了五种化合物(A、B、C、D和E),其中化合物B、C、D和E为新化合物。化合物的结构经IR、1H-NMR及MS等测试技术表征确证。并用二甲苯致小鼠耳肿胀模型对其进行抗炎活性筛选。结果表明,化合物表现出明显的抗炎活性(P<0.01)。

Five compounds were synthesized by coupling paeonol or its analogues with ibuprofen using DCC method or acyl chloride method. All the synthesized compounds were new,except for compound A. The structures of all synthesized compounds were characterized by IR,1H NMR and mass spectrometry. Anti-inflammatory activities of the compounds were evaluated in xylene-induced mice ear swelling model. The results showed that the synthesized compounds exhibited potent anti-inflammatory activities（ P〈0. 01）.