台州地区无偿献血者人类嗜T淋巴细胞白血病病毒感染情况调查

Investigation on the situation of volunfeer blood donors infected with human T lymphotropic leukemia in Taizhou

目的了解台州地区无偿献血者中人类嗜T淋巴细胞白血病病毒(HTLV)感染情况。方法采用双抗原夹心酶联免疫法筛检,筛查阳性反应者双孔复检,仍阳性反应者用核酸试验(PCR)及免疫印迹法(WB)进行确证。结果台州本地户籍献血者6 576名发现抗-HTLV-I阳性2例,PCR及WB确证试验仍为阳性(阳性率0.03%),其为无症状定期献血者,均在本市有4次合格献血经历。2例HTLV-I阳性者均分布于台州东南沿海地区。非台州户籍献血者2193名,抗-HTLV结果均为阴性。台州地区无偿献血者抗-HTLV-I阳性率为0.023%。结论目前台州地区无偿献血者人群抗-HTLV感染率尚处于1个较低水平。

Objective To understand the situation of Taizhou blood donors infected with human T lymphotropic leukemia virus( HTLV). Methods Screening was conducted using sandwich ELISA. Those who were screened positive and reactive were reexamined. Lastly,those who remained positive and reactive were confirmed by nucleic acid test( PCR) and Western blot( WB). Results Among 6 576 blood donors who were local residents in Taizhou,2 cases were identified positive for anti-HTLV-I,and were confirmed positive by PCR and WB confirmatory test at a rate of 0. 03%. They were asymptomatic regular donors,with both had 4 times of qualified blood donation experience in this city. These two cases of HTLV-I positive were distributed in the southeast coastal area of Taizhou province. There were 2 193 blood donors who were not residents in Taizhou,of which their anti-HTLV results were negative. The positive rate of anti-HTLV-I in blood donors in Taizhou was0. 023%. Conclusion The anti-HTLV infection rate of volunteer blood donors in Taizhou is still at a relatively low level.