妊娠肝内胆汁淤积症孕妇血清总胆汁酸浓度与胎儿窘迫相关研究

Correlation Study on Gestation Intrahepatic Cholestasis of Pregnancy Serum Total Bile Acid Concentration and Fetal Distress

目的：探讨妊娠肝内胆汁淤积症孕妇血清总胆汁酸浓度与胎儿窘迫的关系。方法选择2013年6月～2014年6月在我院分娩的妊娠期内胆汁淤积症孕妇84例作为研究组，再选择同期分娩的正常孕妇84例作为对照组，对比两组胎儿窘迫的发生率、血清总胆汁酸浓度，同时记录不同浓度总胆汁酸浓度与胎儿窘迫率的关系。结果研究组胎儿窘迫率为79.76%、血清总胆汁酸浓度为（39.42±6.13）μmol/l均高于对照组，P＜0.05，差异具有统计学意义，且随着总胆汁酸浓度的增加胎儿窘迫率提高。结论妊娠肝内胆汁淤积症孕妇血清总胆汁酸浓度与胎儿窘迫密切相关。

Objective To explore the relationship between gestation intrahepatic cholestasis disease of pregnancy serum total bile acid concentration with fetal distress. Methods Selected 84 cases with gestation Intrahepatic cholestasis from June 2013 to June 2014 in our hospital as the research group, selected 84 cases with puerperal pregnant woman the same period as the control group, compared two groups the incidence of fetal distress, serum total bile acid concentration, record the different concentrations of total bile acid concentration and the relationship between the rate of fetal distress. Results The research group the fetal distress rate was 79.76%, serum total bile acid concentration （39.42±6.13） μmol/l was higher than that of control group, P〈0.05,had difference statistically signiifcance, and with the increase of total bile acid concentration higher rate of fetal distress. Conclusion The intrahepatic cholestasis of pregnancy women is related to the serum total bile acid concentration and fetal distress.