替吉奥联合奥沙利铂治疗进展期胃癌的疗效分析

Analysis of Curative Effect on S-1 Combined With Oxaliplatin in the Treatment of Advanced Gastric Cancer

目的：分析应用替吉奥联合奥沙利铂方案治疗进展期胃癌的疗效和安全性，为治疗进展期胃癌寻找标准方案。方法收集68例进展期胃癌患者资料，对其进行替吉奥联合奥沙利铂治疗期间的资料进行回顾性分析。所有患者均为口服替吉奥40 mg/m2，每日服用两次，第1~14天；21天为一个疗程，第一天静脉注射奥沙利铂100 mg/m2。结果所有患者完全缓解8例（11.76%），部分缓解23例（33.82%），总有效为45.58%。治疗中主要不良反应有骨髓抑制、胃肠道反应、乏力和手足综合征以及周围神经病变。结论应用替吉奥联合奥沙利铂治疗进展期胃癌能够取得较好的疗效，此外不良反应能够耐受，具有临床研究意义。

Objective Efifcacy and safety of application of S-1 combined with oxaliplatin in the treatment of advanced gastric cancer, looking for a standard scheme for the treatment of advanced gastric cancer. Methods Collected 68 cases of advanced gastric cancer patients during data, S-1 combined with oxaliplatin in the treatment of the data were retrospectively analyzed. All patients were treated with S-1 40 mg/m2, take two times a day, 1~14 days, 21 days for a course of treatment, the first day of intravenous oxaliplatin 100 mg/m2. Results All patients with complete remission, 8 cases （11.76%） and partial in 23 cases （33.82%）, the total effective was 45.58%. Major adverse reactions in treatment with bone marrow suppression, gastrointestinal tract reaction, fatigue and extremities syndrome and peripheral neuropathy. Conclusion Application of combined treatment of oxaliplatin into for gonow advanced gastric cancer can obtain a better curative effect, and adverse reactions that can tolerate, clinical research signiifcance.