替罗非班联合尿激酶治疗青年人心肌梗死42例临床观察

Effect of UK combined with tirofiban in young patients with ST segement elevation acute myocardial infarction

目的：研究尿激酶联合替罗非班在青年人 ST 段抬高性急性心肌梗死（STEMI）中的溶栓效果与安全性。方法76例青年 STEMI 患者根据数字表法随机分为观察组（替罗非班联合尿激酶静脉溶栓，42例）和对照组（尿激酶静脉溶栓，34例），比较两组患者梗死相关血管（IRA）再通率、心肌梗死溶栓治疗（TIMI）血流、并发症发生率。结果观察组梗死血管再通率为97．6％，对照组为91．2％，两组差异无统计学意义（χ2＝1.564，P ＞0．05）；观察组 TIMI 血流再通率为90．5％，高于对照组的70．6％（χ2＝4．945，P ＜0．05）；两组死亡、出血发生率差异均无统计学意义（χ2＝1．252、2．837、2．837，均 P ＞0．05）。结论青年人心肌梗死静脉溶栓 IRA 再通率高，联合应用替罗非班治疗 STEMI，能够改善 TIMI 血流分级，且安全性好。

Objective To study the thrombolysis effect and safety of UK combined with tirofiban in young patients with ST segement elevation acute myocardial infarction.Methods 76 young patients with ST segement elva-tion acute myocardial infarction were selected as research objects,and they were divided into UK group（control group, n =34）and UK combined with tirofiban group（observation group,n =42）by random number table,then the recanali-zation rate of infarct -related artery and incidence of complications were compared.Results The recanalization rate of infarct -related artery in the observation group was 97.6%,which was 91.2% in the control group,there was no significant difference between the two groups（χ2 =1.564,P 〉;0.05）;The vascular infarction related to blood flowⅡlevel of the patients was 90.5% in the observation group,which was significantly higher than 70.6% in the control group（χ2 =4.945,P 〈0.05）;The death,complications incidences had not significant differences between the two groups（χ2 =1.252,2.837,2.837,all P 〉;0.05）.Conclusion The thrombolysis effect of UK has a high recanaliza-tion rate of infarct -related artery in young patients with ST segement elevation acute myocardial infarction,and the thrombolysis effect of UK combined with tirofiban is better,and it does not increase the incidence of complications.