微波分离联合戊酸雌二醇口服治疗宫颈锥切术后宫颈粘连的疗效观察

Efficacy of oral estradiol valerate combined with microwave separation treatment of cervical carcinoma in si-tu of the cervix conization cervical adhesions

目的：观察微波分离联合戊酸雌二醇口服治疗宫颈原位癌宫颈锥切术后宫颈粘连的临床效果。方法选择给予微波分离治疗的宫颈粘连患者82例（因宫颈原位癌行宫颈锥切术后发生宫颈粘连）为对照组；另选择宫颈粘连患者86例（因宫颈原位癌行宫颈锥切术后发生宫颈粘连）为观察组，给予微波分离联合戊酸雌二醇口服治疗，比较两组疗效及不良反应情况。结果观察组和对照组治疗1个月后，子宫内膜厚度分别为（8．56±2．54）mm 和（7．96±2．64）mm，均显著优于治疗前的（4．38±1．90）mm 和（4．36±2．10）mm。且观察组的子宫内膜厚度优于对照组（均 P ＜0．05）；治疗3个月后，对照组宫腔粘连患者治愈率为63．41％，总有效率为82．93％；观察组宫腔粘连患者治愈率为70．93％，总有效率为91．86％，两组治愈率和总有效率差异均有统计学意义（χ2＝5．48，P ＜0．05）；治疗后1个月，观察组患者月经改善率（95.35％）优于对照组（89．02％），差异有统计学意义（χ2＝6．38，P ＜0．05）。对照组和观察组的不良反应发生率分别为9．76％和3．49％（χ2＝7．25，P ＜0．05）。结论微波分离联合戊酸雌二醇口服治疗宫颈原位癌宫颈锥切术后宫颈粘连临床有效率高，不良反应小，值得临床推广应用。

Objective To investigate the microwave separation combined oral estradiol valerate treatment of cervical carcinoma in situ of the clinical effects of postoperative adhesions cervical conization.Methods Microwave separation treatment was given to 82 patients with cervical adhesions （for cervical carcinoma in situ in line of the cer-vical cone postoperative cervical adhesion）for the control group;86 patients with select cervical adhesion （for cervi-cal carcinoma in situ in line of the cervical cone postoperative cervical adhesion）for the observation group and gyne-cology （because of cervical carcinoma in situ cervical conization of cervical adhesions）,estradiol valerate give micro-wave separation combined oral treatment,compare two groups and adverse reactions.Results After treatment a month,endometrial thickness,respectively （8.56 ±2.54）mm and （7.96 ±2.64）mm,and were significantly better than before treatment （4.38 ±1.90）mm and （4.36 ±2.10）mm.Endometrial thickness of the observation group was better than that in the control group（P 〈0.05 ）;after three months of treatment,caused by intrauterine adhesions patients in the control group was 63.41%,total effective rate was 82.93%;Caused by intrauterine adhesions in the observation group cure rate was 70.93%,total effective rate was 91.86%,the total cure rate and total effective rate, the difference between the two groups had statistical significance （χ2 =5.48,P 〈0.05）;After treatment a month,the observation group of patients with menstrual period 95.35% better than the control group 89.02%,difference was sta-tistically significant （χ2 =6.38,P 〈0.05）.The incidences of adverse reactions in the control group and observation group were 9.76% and 3.49% respectively （χ2 =7.25,P 〈0.05）.Conclusion Microwave separation combined oral estradiol valerate treatment of cervical carcinoma in situ cervical conization cervical adhesions had clinically effec-tive rate,side effects,which is worthy of clinical application.