米非司酮配伍米索前列醇加用辣椒素终止早期妊娠的疗效观察

Observation on Efficacy of Additional Capsaicin on the Basis of Mifepristone Combined with Misoprostol in Terminating Early Pregnancy

目的:观察米非司酮配伍米索前列醇加用辣椒素终止早期妊娠的疗效。方法:选择2012年2月—2014年2月在云南省第三人民医院就诊的孕龄在10周内要求终止妊娠的妇女400例,随机分为研究组和对照组,每组200例。2组均采用药物流产,服药剂量及方法相同;研究组加用辣椒素口服。比较2组的流产率、胚囊排出时间、阴道流血时间及月经复潮时间。结果:研究组完全流产率高于对照组(P<0.05);研究组胚囊排出时间、阴道流血时间及月经复潮时间均显著短于对照组(P<0.05)。结论:辣椒素配合流产药物终止早期妊娠能提高完全流产率,缩短阴道流血时间,减少子宫出血,提高药物流产的治疗效果。

Objective：To observe the efficacy of additional capsalcin on the basis of mifepristone combined with misoprostol in terminating early pregnancy .Methods：A total of 400 women with gestational age at 10 weeks ,who wanted to terminate the pregnancy in the third people′s hospital of Yunan province from Feb 2012 to Feb 2014 ,were randomly divided into the control group and the study group ,with 200 cases in each group .Both the groups were given drug‐induced abortion with same dosage and method .The study group was added with capsalcin .The abortion rate ,the embryo sac discharge time ,vaginal bleeding time and menstruation recovery time of the two groups were compared with each other .Results：The complete abortion rate in the study group was higher than that in the control group（P〈0 .05） .The embryo sac discharge time ,the vaginal bleeding time , menstruation recovery time in the study group were significantly shorter than those in the control group （ P〈 0 .05 ） . Conclusions：For terminating early pregnancy ,capsalcin combined with abortion medications could shorten the period of vaginal bleeding ,decrease the uterine bleeding volume ,and improve the efficacy of drug‐induced abortion .