参苓白术散分期干预脾胃亏虚艾滋病随机平行对照研究

Randomized Parallel Group Study of Canlingbaizhu Casual Intervening Patients with Spleen Deficiency Type AIDS in Different Periods

[目的]观察参苓白术散分期干预脾胃亏虚艾滋病疗效。[方法]使用随机平行对照方法,将154例住院及门诊患者分期按就诊顺序号方法简单随机分四组,潜伏期分中医治疗组与对照组,发病期分联合治疗组与西医治疗组。潜伏期:对照组44例不使用任何药物;中医治疗组42例参苓白术散颗粒剂(人参、茯苓、白术、山药、莲子、白扁豆、薏苡仁、砂仁、桔梗、甘草),10g/次,3次/d,温水冲服。发病期:西医治疗组34例一线抗病毒药物;联合治疗组34例参苓白术散颗粒剂与一线抗病毒药物治疗同中医治疗组和西医治疗组。连续治疗12周为1疗程。观测临床症状、CD4+T淋巴细胞、肝功能、血常规、中医症候、不良反应。连续治疗4疗程,判定疗效。[结果]CD4+T淋巴细胞四组均有改善(P<0.05),联合治疗组、中医治疗组改善分别优于西医治疗组、对照组(P<0.05)。发病期中医症候积分两组均有明显降低(P<0.05),治疗组降低优于对照组(P<0.05)。发病期肝功能、血常规白细胞变化均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]参苓白术散分期干预脾胃亏虚艾滋病,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the efficacy of Canlingbaizhu casual intervening patients with spleen deficiency type AIDS in different periods.[Methods] Using randomized parallel control method, the 154 cases（ inpatient / outpatient） treatment in patients with stage according to the sequence number method, simply randomly divided into four groups. The incubation period was divided into Chinese medicine treatment group and the control group, and the incidence period was divided into the combined treatment group and Western medicine treatment. The incubation period： 44 cases in the control group did not use any medication, and TCM treatment group, 42 patients taking Canlingbaizhu casual scattered granules,（renshen,fulin,baizhu,sha nyao,baibiandou,yiyiren,sharen,jiegeng,gancao）,10 g / time, 3 times / d, warm water. The incidence period ： 34 patients of western medicine treatment group taking first-line antiviral drugs; 34 patients of combined treatment group taking Canlingbaizhu casual scattered granules and the first antiviral treatment. 12 weeks of continuous treatment for a course of treatment. Observation of clinical symptoms, CD4 ＋ T lymphocytes, liver function, blood, TCM symptoms of adverse reactions. 4 courses of continuous treatment, to determine efficacy.[Results] CD4＋T lymphocytes in the four groups were improved（P0.05）.Combination therapy group, Chinese medicine treatment group were better than western medicine to improve the treatment group and control group（P〈0.05）. The symptom scores of incidence period decreased significantly in both groups（P〈0.05）, treatment group Lower than the control group（P〈0.05）. The changes of liver function and blood leukocytes were improved in the incidence period（P〈0.05）, the treatment group improved than the control group（P〈0.05）. [Conclusion] Canlingbaizhu casual intervened patients with spleen deficiency type AIDS in different periods, results were satisfactory, no serious adverse reactions, should be promoted.