疏肝健脾汤治疗腹泻型肠易激综合征多中心随机平行对照研究

Shugan Jianpi Decoction in Treating Diarrhea Type Irritable Bowel Syndrome of Multi Center Randomized Parallel Control

[目的]观察疏肝健脾汤治疗腹泻型肠易激综合征疗效。[方法]使用多中心随机平行对照方法,将125例门诊患者按就诊顺序编号简单随机分为两组。对照组62例蒙脱石散,6g/次,3次/d。治疗组63例疏肝健脾汤(党参30g,炒白术、白扁豆各15g,茯苓30g,炒山药15g,木香6g,葛根20g,黄连6g,醋香附、柴胡、炒白芍各12g,仙鹤草20g,桔梗9g,防风3g,焦三仙10g;腹痛加川楝子、延胡索;腹泻严重加诃子、赤石脂;晨起五更泻加补骨脂、肉豆蔻;腹胀加厚朴),1剂/d,水煎200m L,早晚口服。连续治疗4周为1疗程。观测临床症状、腹痛、腹胀、腹泻、不良反应。治疗1疗程,判定疗效。随访6个月,观测病情变化及药物不良反应。[结果]治疗组临床痊愈14例,显效30例,有效15例,无效4例,总有效率93.65%。对照组临床痊愈10例,显效22例,有效17例,无效13例,总有效率79.03%。治疗组疗效优于对照组(P<0.05)。症状积分两组均有明显降低(P<0.05),治疗组降低优于对照组(P<0.05)。[结论]疏肝健脾汤治疗腹泻型肠易激综合征,疗效满意,无严重不良反应,值得推广。

[Objective]To research the effect of Shugan Jianpi Decoction in traetment of irritable bowel syndrome（IBS）.[Method] Using a randomized controlled method, 125 cases of clinical patients into two groups according to clinical number. The control group of 62 cases of Montmorillonite powder, 6g,tid. Treatment group cases Shugan Jianpi Decoction, 1/d, boiling 200 ml. Continuous treatment of 4 weeks for 1 course of treatment. Observation of clinical symptoms, abdominal distension, abdominal pain, diarrhea and adverse reactions. As a course treatment, judge curative effect. Follow up six months, judge curative and adverse reactions.[Results] The treatment group 14 cases cured, 30 cases were markedly effective, effective in 15 cases, 4 had no effect, the total effective rate was 93.65%. Control group 10 cases cured, 22 cases were markedly effective, effective in 17, 13 had no effect, the total effective rate was 79.03%. The treatment group curative effect is better than that of control group（P〈0.05）. Symptom scores of two groups were obviously decreased, and the treatment group was better than control group（P〈0.05）. [Conclusion] Shugan Jianpi Decoction treatment of irritable bowel syndrome,results were satisfactory,no side effects,it is worth promoting.