二甲基甲酰胺累积接触量与肝损伤的剂量-反应关系研究

Study on dose-response relationship between DMF cumulative exposure dose and liver injury

目的探索二甲基甲酰胺(DMF)累积接触量与肝损伤的剂量-反应关系。方法选取6家皮革制造企业847名工人2012年3月—2013年9月期间的职业健康检查资料和历年接触DMF的监测资料,应用Kaplan-Meier法结合三参数Weibull分布拟合的方法,建立DMF累积接触量与肝损伤的剂量-反应关系曲线,并估算出发生肝损伤的DMF累积接触阈值。结果 DFM累积接触量与肝损伤累积发病率的剂量-反应关系曲线为F=1-exp[-0.021×(T-41.3)0.421],发生肝损伤的DMF累积接触阈值为41.3(mg/m3)·月。结论 DMF累积接触量与肝损伤之间存在明显的剂量-反应关系,提示有关部门应采取相关预防控制措施来切实保护作业工人的健康。

[ Objective ]To study the dose-response relationship between dimethylformamide （DMF） cumulative exposure dose and liver injury. [ Methods]The oecupational health examination data of 847 workers from 6 leather manufacturing enterprises during March 2012-September 2013, and their DMF exposure data over the years were collected. Kaplan-Meier method combined with three parameters Weibull distribution was used to establish the dose-response relationship curve and estimate the DFM cumulative exposure threshold.[ Results ]The dose-response relationship curve between DFM accumulative exposure does and liver injury was F=1-exp [-0.021 ×（T-41.3）0.421], and the DMF cumulative exposure threshold was 41.3 （mg/m3） ·M. [Conclusion]The dose- response relationship between DMF cumulative exposure dose and liver injury is obvious, and the results could serve as a scientific basis for taking control measures to protect workers＂ health.