血清LDH水平对老年肝癌患者介入治疗的远期预后分析

Analysis of serum LDH level in long-term prognosis of liver cancer in elderly patients undergoing interventional treatment

目的研究血清LDH的水平对老年肝癌患者介入治疗的远期预后评估价值。方法选取2010年7月-2012年12月在我院行肝动脉化疗栓塞术的120例老年肝癌患者作为研究对象,根据术前血清乳酸脱氢酶(LDH)水平将患者分为观察组(LDH>400 U/L)54例和对照组(LDH≤400 U/L)66例,跟踪随访两组介入治疗后的远期预后情况。结果两组血清LDH在术后1 d均无明显变化,术后1 w、1个月、6个月、1年血清LDH均明显降低,且对照组明显低于观察组(P<0.05);术后2年两组血清LDH降低幅度变缓,且两组间无明显差异(P>0.05)。术后1年观察组疗效显著的患者数明显少于对照组(P<0.05);术后2年血清LDH升高患者的疗效显著率、疗效尚可率均明显低于血清LDH降低患者(P<0.05)。结论血清LDH水平测定可作为判定老年肝癌患者介入治疗远期预后的指标,并为临床制定治疗方案提供相应的依据。

Objective To study the assessment value of serum LDH level in long-term prognosis of liver cancer in elderly pa- tients undergoing interventional treatment. Methods From July, 2010 to December, 2012, 120 cases of elderly patients with hver cancer who received hepatic artery chemoembolization in our hospital were regarded as the research object. Based on preoperative serum lactate dehydrogenase （LDH） levels, all patients were divided into the observation group （LDH 〉 400U/L） 54 cases and the control group （ LDH ≤400U / L） 66 eases. Then we analyzed the patients of two groups involved in long-term prognosis after treatment. Re- suits The serum LDH of the observation group and the control group did not change significantly 1 day after treatment ; the serum LDH of two groups were significantly lower 1 week, 1 month, 6months, 1 year after surgery, and the serum LDH of the control group was significantly lower than the observation group, the serum LDH of two groups of patients after 2 years of reduced the magnitude of slo- wing down （P 〉 0. 05） ; 1 year after surgery, significantly effective patients of the observation group were significantly less than that of the control group （P 〈 0. 05 ）, and the patients with poor or no therapeutic efficacy of the observation group were significantly more than the control group ; 2 years after surgery, the significant effect rate and the good effect rate of the patients with elevated serum LDH was significantly lower than the patients with depressed serum LDH; poor or no therapeutic efficacy rate of patients with elevated serum LDH was significantly higher than he patients with depressed serum LDH; difference in efficacy between the two groups were statistical- ly significant （P 〈 0. 05）. Conclusion Serum LDH levels can be regarded as judgment of interventional treatment of liver cancer in elderly long-term prognosis, and provide a corresponding basis for the develooment of clinical treatment.