加味玉屏风胶囊治疗COPD缓解期气虚质患者临床观察

Clinical Observation on Treatment of COPD Patients of Qi Deficiency in Remission Stage by the Modified YuPinFeng Capsule

目的观察加味玉屏风胶囊对慢性阻塞性肺疾病(COPD)缓解期气虚型患者的临床疗效。方法将60例COPD缓解期气虚型患者随机分为治疗组和对照组,每组30人,对照组给予吸氧、解痉、止咳、化痰等常规治疗;治疗组在对照组的基础上加用玉屏风胶囊口服,10天为一个疗程,连续治疗60天,对比两组治疗前、后肺功能及中医症状体征积分。结果治疗组总有效率为83.33%,对照组为63.33%,治疗组疗效优于对照组,差异有统计学意义(P<0.05);治疗组患者治疗后肺功能FEV1、FEV1/FVC改善情况及咯痰、喘促、自汗、懒言、畏风等中医症状体征积分下降程度均优于对照组,差异有统计学意义(均P<0.05)。结论加味玉屏风胶囊治疗气虚型COPD缓解期疗效显著。

Objective： To observe the clinical effects of the Modified YuPinFeng Capsule （ the Modified Jade Screen Capsule） on COPD patients in the remission stage. Methods： Overall 60 COPD patients of remission stage were random- ized into treatment and control groups with 30 cases in each. The conventional therapies, such as oxygen inhalation, spas- molysis, antitussiveness and expectoration, were administered to the cases of control group; while besides the conventional methods, the eases of treatment group were orally given the Modified YuPinFeng Capsule. A course was 10 days and the treatment lasted for 60 days. Finally, the lung functions and the indexes of TCM symptoms as well as signs were compared between the two groups before and after treatment. Results： The total effective rate of the treatment group was 83.33 % superior to the control group 63.33 % and the difference between them had statistical meanings （ P〈0. 05 ）. After treatment, the improvement of patients＇ lung functions （ FEV1, FEV1/FVC）, TCM indexes of expectoration, asthma, spontaneous perspiration, disinclination to talk as well as aversion to wind in the treatment group were all better than those of the control group and the difference between the two groups had statistical meanings （P〈0. 05 ）. Conclusion： The Modified YuPinFeng Capsule has marked effects on COPD patients of qi deficiency constitutions in remission stage.