摘要
目的建立昆明山海棠片HPLC指纹图谱。方法采用HPLC法,用中药色谱指纹图谱相似度评价系统2004A(国家药典委员会)对20批昆明山海棠片制剂的数据进行分析、建立其指纹图谱,并对该方法进行方法学验证。结果不同批次样品图谱相似度均在0.9以上,色谱方法可靠。结论建立的指纹图谱能较全面地反映了制剂的质量,其方法可靠且简单易行,具有较好的重复性、适应性,为昆明山海棠片的整体质量评价提供科学依据。
Objective: To establish the HPLC (high performance liquid chromatography ) fingerprints for the Tripterygium Hypoglaucum Tablet. Methods: The data of 20 batches of Tripterygium Hypoglaucum Tablets were analyzed to establish the fingerprints with "similarity evaluation system for chromatographic fingerprint of TCM" ( version 2004A made by Natinal Pharmacopoeia commission) by HPLC and the established method was methodologically verified. Resuits: The similarity of the different batches was higher than 0.9 and the method was reliable. Conclusion: The established fingerprints can comprehensively reflect the qualities of the tablet and this method is easy, safe and feasible with good repeatability and adaptability to lay a scientific basis for the evaluation of the overall quality of the Tripterygium Hypoglancum Tablet.
出处
《陕西中医学院学报》
2015年第3期88-91,共4页
Journal of Shaanxi College of Traditional Chinese Medicine
基金
重庆市科委集成示范项目(cstc2013jcsf10011)
重庆市科委科技平台与基地建设(科研院所创新能力建设)项目(cstc2012pt-kyys10004)
重庆市科委科技平台与基地建设(科研院所创新能力建设)项目(cstc2012pt-kyys10001)