大黄、芒硝脐敷对肝硬化腹水患者血清IL-6、TNF-α的影响

Effects of Daihuang(Rhubarb) and Mangxiao(Mirabilite) Umbilicus Application on Serum IL-6 and TNF-α Levels in Liver Cirrhosis Patients with Ascites

目的:观察大黄、芒硝脐敷对肝硬化腹水患者的临床疗效及对TNF-α和IL-6的影响。方法:将60例肝硬化腹水患者随机分为治疗组30例和对照组30例,对照组给予常规治疗,治疗组在常规治疗的基础上加用大黄、芒硝脐敷,每日1次,连用2周。观察两组临床疗效以及治疗前后血清TNF-α、IL-6含量的变化。结果:两组临床疗效比较,差异有统计学意义(P<0.05)。两组治疗后血清TNF-α、IL-6水平均明显下降,治疗组效果较对照组显著,差异均有统计学意义(P<0.05)。结论:大黄、芒硝脐敷对肝硬化腹水有辅助治疗作用,能显著降低肝硬化腹水患者TNF-α、IL-6水平。

Objective：To observe the clinical curative effect of rhubarb and mirabilite umbilicus application in cirrhotic patients with ascites and influence on serum TNF - a and IL -6. Methods ：60 cases of ascites due to cirrhosis were divided into treatment group and control group, each contained 30 cases, control group was given conventional therapy, treatment group was given rhubarb and mirabilite umbilicus application on the basis of con- trol group, once a day, for 2 weeks. To observe the curative effect of the two groups and the changes of serum TNF - a, IL -6 contents before and after treatment. Results：To compare the curative effect of the two groups, the difference was statistically significant （ P 〈 0. 05 ）, serum TNF - a and IL - 6 levels were obviously de- creased in the two groups after treatment, the effect in the treatment group was more significant （P 〈 0. 05）. Conclusion： Rhubarb and mirabilite umbilicus application is effectively adjuvant therapy for liver cirrhosis pa- tients with ascites, reducing serum IL - 6 and TNF - a levels was the one of the mechanism.