促性腺激素释放激素受体在宫颈上皮内瘤样病变中表达及临床意义

Expression of Gonadotropin - releasing Hormone Receptor in Cervical Intraepithelial Neoplasia and Its Clinical Significance

目的：探讨促性腺激素释放激素受体（GnRHR）在宫颈上皮内瘤样变中表达及其临床意义。方法：采用免疫组织化学SP法和免疫蛋白印迹检测43例宫颈上皮内瘤样变（CIN）其中标本中GnRHR的表达。结果：宫颈上皮内瘤样变中，GnRHR呈阳性表达，在CINI、CINU和CINm组织中GnRHR表达率和表达量呈增高趋势，3组比较差异有统计学意义（P〈0．05）。结论：CIN表达GnRHR，CIN中异型性的鳞状上皮细胞自身可能合成GnRHR，且在CIN中GnRHR阳性表达情况与细胞异型程度有关，GnRHR可能参与CIN细胞增殖。

Objective ：To investigate the expression of gonadotropin- releasing hormone receptor （GnRHR） in cervical intracpithelial neoplasia （ CIN ） and its potentially clinical significance. Methods ： The expression of GnRHR was detected by immunohistochemical SP and western blot methods in 43 cases of CIN. Results：The expression of GnRHR was positive in CIN cells. The expression rate and vol- ume of GnRHR increased in CIN I , CIN II and CIN m tissue , there was significant difference between three groups （ P 〈 0.05）. Con- clusion：The GnRHR is expressed in human CIN. And it may be produced by heterotypically squamous cells,and among the groups of CIN, the positive expression for GnRHR related to the severity of cell heteromorphism. The results also suggested that GnRHR may take part in the cell proliferation of CIN.