西酞普兰与氟西汀治疗中国老年抑郁症患者的系统评价

Citalopram vs. Fluoxetine in Treatment of Senile Patients with Depression in China: A Systematic Review

目的：比较西酞普兰与氟西汀治疗中国老年抑郁症患者的疗效和不良反应发生率。方法：收集1994—2013年国内所有关于西酞普兰与氟西汀治疗老年抑郁症的随机对照研究文献,应用系统评价方法对检索到的11篇随机对照研究文献进行定量综合分析。结果：西酞普兰与氟西汀的疗效差异无统计学意义[P〉0.05,OR=1.17,95%CI（0.81-1.68）],氟西汀组头痛、出汗发生率较酞普兰组多见,差异有统计学意义（P〈0.05）。其他不良反应发生率差异无统计学意义（P〉0.05）。结论：西酞普兰与氟西汀治疗中国老年抑郁症患者的疗效相似,西酞普兰较氟西汀不良反应轻微。

OBJECTIVE：To compare the clinical efficacy and the adverse reactions between citalopram and fluoxetine in treatment of senile patients with depression in china. METHODS： A total of 11 papers about controlled study comparing clinical efficacy and the adverse reactions between citalopram and fluoxetine for senile patients with depression retrieved from 1994 to 2013 in China were subjected to a meta-analysis. RESULTS： There was no significant difference in clinical efficacy between citalopram and fluoxetine （P 〉 0. 05, OR = 1.17, 95% CI （0. 81 - 1.68 ）. The incidence rate of headache and sweating in fluoxetine group were significantly higher than in citalopram group （ P 〈 0.05 ）. There were no significant differences in incidence rates of other adverse reactions between the two groups （ P 〉 0. 05 ）. CONCLUSION： Citalopram is as effective as fluoxetine as antidepressants in senile patients in China with similar efficacy, and the adverse drug reaction of citalopram is mild.