鼻内镜下手术结合术后鼻窦冲洗治疗变应性真菌性鼻窦炎的临床研究

The Clinical Research of Endoscopic Surgery Combined with Postoperative Sinus Rinse in Treatment of Allergic Fungal Sinusitis

目的:研究鼻内镜下手术结合术后鼻窦冲洗治疗变应性真菌性鼻窦炎的临床疗效。方法:选取2010年3月到2013年3月我院收治的变应性真菌性鼻窦炎患者67例为研究对象,对其临床资料进行回顾分析,所有患者均给予鼻内镜下手术结合术后鼻窦冲洗治疗,术后随访患者1年。另选取健康者50例为对照组,应用视觉模拟量表(VAS)评价患者术前术后主观感受,应用鼻内镜和鼻腔纤毛功能评价患者术前术后客观感受,并应用生活质量量表(SF-36)评价患者的生活质量。结果:患者术后VAS评分为(18.5±1.3)分显著优于术前的(29.3±0.2)分,与术前比较差异具有统计学意义(t=11.026,P=0.018);术后鼻内镜总分为(4.1±0.2)分显著优于手术前,与手术前比较差异具有统计学意义(t=9.037,P=0.027);术后1年鼻纤毛传输速度(6.9±0.3)mm/min,与对照组比较差异无统计学意义(t=3.984,P=0.092);术后1年SF-36评分为(649.6±23.2)分,与对照组比较差异无统计学意义(t=4.018,P=0.096)。结论:鼻内镜下手术结合术后鼻窦冲洗治疗变应性真菌性鼻窦炎具有较好的临床疗效,能显著改善患者的症状,提高患者的生活质量。

Objective： To study the clinical efficacy of endoscopic surgery combined with postoperative sinus rinse in treatment of allergic fungal sinusitis. Methods： 67 cases of patients with allergic fungal sinusitis who were treated in our hospital from March 2010 to March 2013 were selected, and the clinical data of them were retrospectively analyzed. All patients were treated with endoscopic sinus surgery combined with postoperative sinus rinse, and patients were followed up for 1 year postoperative. 50 cases of healthy people were selected as the control group, the subjective preoperative and postoperative feelings of patients were evaluated by visual analogue scale（VAS）, the objective preoperative and postoperative feelings of patients were evaluated by functional endoscopic sinus and nasal cilia,and the quality of life of patients were evaluated by quality of life questionnaire（SF-36）. Results： The postoperative VAS scores were（18.5±1.3） points, significantly better than（29.3±0.2） points of preoperative scores（t=11.026, P=0.018）; The postoperative endoscopic score were（4.1±0.2） points, significantly better than preoperative ones, the difference was statistically significant（t=9.037,P=0.027）; The nasal mucociliary transporting velocity after 1 year was（6.9 ±0.3）mm/min, and the difference was not statistically significant when compared with the control group（t=3.984, P=0.092）; the SF-36 scores after 1 year were（649.6 ±23.2） points, with no statistically significant difference when compared with that in the control group（t=4.018, P=0.096）. Conclusion： Endoscopic surgery combined with postoperative sinus rinse in treatment of allergic fungal sinusitis has better clinical efficacy, can significantly improve the symptoms, and improve the life quality of patients.