枸橼酸莫沙必利对老年功能性消化不良患者胃功能的影响

Effect of Mosapride Citrate on Stomach Function of Elderly Patients with Functional Dyspepsia

目的：探讨枸橼酸莫沙必利分散片对老年功能性消化不良（FD）患者胃功能的影响。方法：将2012年3月-2014年3月我院79例老年FD患者（FD组）给予口服枸缘酸莫沙必利分散片,并随机抽取同一时期120例我院健康体检者为对照组,检测并比较两组的胃底气体的评分、延迟排空相、近端胃容积以及近端胃液体半排空时间。结果：FD组治疗前延迟排空相大于对照组,近端胃液体半排空时间小于对照组,差异有统计学意义（P〈0.05）,两组的胃底气体的评分差异无统计学意义（P〉0.05）;FD组治疗后延迟排空相小于治疗前,近端胃液体半排空时间大于治疗前,差异有统计学意义（P〈0.05）;FD组治疗前0 min、5 min、15 min、30min、60 min的近端胃容积均小于对照组,差异均有统计学意义（P〈0.05）;FD组治疗后各时刻近端胃容积大于治疗前,差异均有统计学意义（P〈0.05）。结论：老年FD患者采用枸缘酸莫沙必利分散片治疗可明显改善患者的胃功能,促进胃排空的速度,值得临床推广。

Objective： To investigate the effect of mosapride citrate dispersible tablets on gastric function of elderly patients with functional dyspepsia. Methods： 79 cases of elderly with functional dyspepsia in our hospital from 2012 March to 2014 March took orally mosapride citrate dispersible tablets（FD group）, 120 healthy people from our hospital during the same time were randomly selected as control group. The stomach gas scoring, delayed emptying phase, the proximal gastric volume and half emptying time of proximal gastric liquid were detected and compared. Results： The delayed emptying phase of FD group before treatment was larger than that of control group, the half emptying time of proximal gastric liquid was less than that of control group, the difference was statistically significant（P〈0.05）, there was no significant difference in stomach gas scoring between the two groups（P〉0.05）; The delayed emptying phase of FD group after treatment was less than that before treatment, the half emptying time of proximal gastric liquid was better than that before treatment, the difference was statistically significant（P〈0.05）; The proximal gastric volume of FD group before treatment 5 min, 10 min,30 min, 60 min were less than those of the control group, and the difference was statistically significant（P〈0.05）; the proximal gastric volume of FD group after treatment each time were larger than those before treatment, and the difference was statistically significant（P〈0.05）.Conclusion： Mosapride citrate dispersible tablets improve the stomach function, and can greatly promote the rate of gastric emptying in the treatment of elderly patients with functional dyspepsia, it is worthy of clinical promotion.