冠状动脉弥漫性长病变治疗的研究进展

The Research Progress of Treatment of Coronary Artery with Diffuse and Long Lesions

冠心病目前已经成为全球性关注的健康问题,为当今人类一大灾难性疾病。既往研究表明,冠状动脉弥漫性长病变占冠心病总患者约20%,冠状动脉弥漫性长病变患者其动脉粥样硬化的病变范围更加广泛,病变呈弥漫性,而且更多累及左主干,常常伴有血管直径小,血管成角、钙化、扭曲等特点,而且多发生于高龄、糖尿病患者中,以上特点又决定了冠状动脉弥漫性长病变成为冠心病治疗的又一难题。因此,有效的预防与治疗冠状动脉弥漫性长病变,已成为目前的关注重点与热点,本文概述了冠状动脉弥漫性长病变临床治疗中的常用方法以及各方法的疗效与优劣之势,多年临床实践经验表明PCI治疗仍占有主导位置,虽然目前冠状动脉弥漫性长病变的介入治疗应用药物洗脱支架的已经取得良好的临床效果,在很大程度降低了心血管事件发生率和再次血管重建率,但药物洗脱支架支架治疗冠状动脉弥漫性长病变的远期疗效仍在评估中。

Coronary heart disease has becomed the global focus on health problems at present, as a major catastrophic diseases nowadays. Previous studies showed that coronary artery with diffuse and long lesions accounted for 20% of the total patients of coronary heart disease（CHD）, the patients of coronary artery with diffuse and long lesions of the atherosclerotic lesions range have more widely,and the lesions often show as diffuse, and more affected LAD, and often have characteristics of small blood vessel diameter, blood vessels into distortion angle, calcification, distorted, etc., and develops in older age, diabetes patients, the above characteristics and determine the coronary artery with diffuse and long lesions was another problem in coronary heart disease therapy. Anyway, effective prevention and treatment of coronary artery with diffuse and long lesions has become the focus at present. This article briefly summarizes the commonly used methods in the clinical treatment of coronary artery with diffuse and long lesions and the curative effects and the advantages and disadvantages of each method. Years of clinical practice experience shows that PCI treatment is still in a dominant position. It can be seen that drug-eluting stents（des） used in the treatment of coronary artery with diffuse and long lesions has good clinical effect. Greatly reduced the incidence of cardiovascular events and vascular remodeling rates again, but the drug-eluting stents long curative effect in treatment of coronary artery with diffuse and long lesions is still in evaluation.