经皮电穴位电刺激足三里穴对胃癌患者术后血清IgG、IgM水平的影响

Effect of Transcutaneous Electrical Acupoint Stimulation on the Postoperative Immunologic Function in Patients with Gastric Cancer Undergoing Radical Surgery

目的：观察经皮穴位电刺激对胃癌根治术患者术后血清免疫球蛋白M（Ig M）、免疫球蛋白G（Ig G）水平的影响。方法：选择全麻择期行胃癌根治术的患者102例（男88例,女14例）,年龄40-75岁,将其随机分为经皮穴位电刺激组、假电刺激组和对照组。经皮电刺激双侧＂足三里＂（ST 36）、＂三阴交＂（SP 6）穴,于手术当日、术后第1日和术后第2日进行经皮电刺激治疗。于术前30分钟、术后24 h、术后72 h采集静脉血标本,测定免疫球蛋白G（Immunoglobulin G,Ig G）、免疫球蛋白M（Immunoglobulin M,Ig M）的水平。术后监测和记录肛门的排气时间。结果：在术后第1天,对照组外周血Ig G水平显著低于术前30分钟（P〈0.05）,TEAS组外周血Ig M水平显著高于术前30分钟（P〈0.05）,TEAS组外周血Ig G和Ig M水平显著高于对照组（P〈0.05）。在术后第3天,对照组外周血Ig G、Ig M水平显著低于术前30分钟（P〈0.05）,TEAS组外周血Ig G、Ig M水平均显著低于术后1天（P〈0.05）。三组患者术后肛门排气时间比较无统计学差异（P〉0.05）。结论：经皮穴位电刺激可以升高胃癌根治术患者术后1天降低的外周血Ig G和Ig M水平,减轻其术后免疫抑制。

Objective： To observe the effect of TEAS（Transcutaneous Electrical Acupoint Stimulation, TEAS）on the postoperative Immunoglobulin M（Ig M） and Immunoglobulin G（Ig G） levels in patients with gastric cancer undergoing radical surgery.Methods： Totally 102 patients with gastric cancer undergoing elective radical surgery under general anesthesia were randomly assigned to three groups, control group, TEAS group and sham group. TEAS group receiving TEAS before general anesthesia induction, 1st day and2 nd day after surgery. TEAS was given through electrodes attached to zusanli（ST 36） and sanyinjiao（SP 6） acupoints. The time for TEAS was 30 min. Venous blood samples from all groups（control group, TEAS group and sham group） were collected before general anesthesia induction, 1st day and 3rd day after surgery. The peripheral blood Ig G and Ig M levels were measured. Anal exhaust time after surgery was also compared among the groups. Results： Ig G levels in peripheral blood decreased significantly compared with those at 30 min before surgery and 1st day after surgery in the control group. It increased significantly compared with those at 30 min before surgery and1 st day after surgery in TEAS group. The peripheral blood Ig G and Ig M levels in TEAS groups increased significantly compared with that of control group at 1st day after surgery; Ig G and Ig M levels in peripheral blood decreased significantly compared with those at30 min before surgery and 2nd day after surgery in the control group. They also decreased significantly compared with those at 1st and2 nd day after surgery in the TEAS group. Conclusion： TEAS could increase the low peripheral blood Ig G and Ig M levels in patients with gastric cancer undergoing radical surgery on the 1st day after surgery. It partially reduced the postoperative immune suppression.