口服营养补充研究进展

Advance of Oral Nutritional Supplement

疾病相关营养不良是住院病人一个重要的不良预后因素,影响病人的生活质量,除去吞咽困难及消化道不健全,当患者摄入不能满足机体的需求时建议给予口服营养补充(ONS)。越来越多的证据证明口服营养补充在营养不良治疗中的重要有利作用,尤其对急性病、老年人及低营养状态的病人效果显著。口服营养补充符合人体生理特点,安全、经济、易于吸收且依从性较好,可以有效改善患者的能量及营养元素的摄取,提高患者的生活质量。ONS越来越多的在临床应用,但其应用时间,具体方法以及临床效果的评价还存在争议,本文从以下几方面对ONS的研究进行综述,介绍ONS的起源与发展,完善ONS的定义,准确评估其临床疗效,具体阐明ONS在肿瘤疾病中的应用,为ONS更好的应用于临床提供比较好的理论依据。

Disease related malnutrition is an important adverse prognostic factor with hospitalized patients, which has poor effect on the quality of life. Oral nutrition support（ ONS） should be considered when patients intake could not meet their requirements, unless they cannot swallow or have incomplete gastrointestinal structure. An increasing number of evidences proved beneficial effect of oral nutritional supplement in the treatment of malnutrition, especially for acute disease, the elderly and the patients in low nutritional status.Oral nutritional supplement accords with human physiological characteristics. It has advantages of safety, economy, easy absorption and better compliance, which can effectively improve the patient＇s energy and nutrient elements, and promote the patient＇s quality of life.Searching relevant literature, ONS is applied more and more widely in clinic, but its application and assessment of clinical effect remains controversial. This review analyses the role of ONS as following several aspects, for introducing the origin and development of the ONS,improving the definition of ONS, accurately evaluating of its clinical effect, elucidating the application of ONS in tumor disease in detail,and providing better theoretical basis for the option of ONS in clinic.