2009—2013年内蒙古自治区乌兰察布市耐多药肺结核患者疗效分析

The therapeutic effect analysis of drug resistant pulmonary tuberculosis patients in Ulanqab in 2009 to 2013

目的 提高耐多药患者治愈率.方法 本研究资料来自内蒙古乌兰察布市全球基金项目,对2009年3月至2013年5月期间登记及治疗的耐多药结核病患者93例进行临床数据分析.结果 给予耐多药治疗的患者病情均有明显缓解,咳嗽、咯痰治疗的总有效率为84.51％（60/71）;胸痛、胸闷治疗的总有效率为85.00％（17/20）;乏力、盗汗治疗的总有效率为62.79％（27/43）;发热治疗的总有效率为94.74％（18/19）;胸部X线及CT检查结核病相关征象好转或消失的总有效率为77.42％（72/93）.治疗成功20例,占31.25％（20/64）;失败9例,占14.06％（9/64）;死亡10例,占15.62％（10/64）;丢失19例,占29.69％（19/64）;其他（2例去外地治疗;4例未完成疗程停药,痰菌检测结果符合治愈）6例,占9.38％（6/64）.结论 耐多药结核病患者经过积极治疗,临床症状和体征均有明显改善,但是治疗成功率仍然不理想,应该引起足够的重视.

Objective To improve the cure rate of multidrug-resistant pulmonary tuberculosis （MDR-TB） patients. Methods The clinical data of 93 MDR-TB patients registered and treated from Mar 2009 to May 2013 were analyzed, and the data were based on Global Fund Project of Ulanqab City in Inner Mongolia. Results The patients＇ conditions were alleviated significantly due to the MDR TB treatment. The total effective rate of cough and expectoration was 84. 51% （60/71）, and for chest pain and chest oppression was 85.00% （17/20）, the total effec- tive rate of fatigue and night sweats was 62.79%（27/43）, and that for fever was 94. 74% （18/19）, the total effec rive rate of chest X-ray and CT was 77.42% （72/93）. Twenty cases were cured （31. 25%, 20/64）, 9 cases were failed （14. 06%, 9/64）, 10 cases were died （15.62%, 10/64）, and 19 cases were defaulted （29.69%, 19/64）, the other 6 cases（2 cases to the field of treatment, 4 patients did not complete the course withdrawal, sputum knot line to cure） account for 9.38%（6/64）. Conclusion Multidrug-resistant tuberculosis patients after treatment, the clini- cal symptoms and signs were obviously improved, but the cure rate of success is still not ideal, should cause enough attention.