增生期子宫内膜异位患者在位与异位子宫内膜组织因子表达的对比

Comparison of the expression of tissue factor between eutopic and ectopic endometrium in patients with proliferative endometriosis

目的对子宫内膜异位(EMs)患者增生期的在位和异位内膜组织因子表达进行分析。方法采用免疫组织化学方法对子宫内膜异位患者增生期在位子宫内膜组织50份(实验A组)、增生期异位子宫内膜组织50份(实验B组)及正常增生期子宫内膜50份样本组织的组织因子表达进行检测,并进行对比分析。结果实验B组子宫内膜组织因子阳性表达率(94.0%)明显高于实验A组(22.0%)和对照组(14.0%),差异有统计学意义(P<0.05或P<0.01);实验A组子宫内膜组织因子阳性表达率与对照组相比,差异也具有统计学意义(P<0.05)。结论增生期子宫异位内膜组织的组织因子阳性表达率较为显著,高表达的组织因子对增生期子宫内膜异位的特异判断和病灶定点靶向治疗能够起到更好的引导作用。

Objective To analyse the expression of proliferative eutopic and ectopic endometrium tissue factor in pa-tients with endometriosis. Methods Detected the tissue factor expression of proliferative eutopic endometrium tissue （50 sam-ples,experiment A group）, proliferative ectopic endometrium tissue （50 samples,experiment B group） in patients with en-dometriosis and normal proliferative endometrium tissue in healthy persons （50 samples,control group）. Compared and analysed the results among the three groups. Results The positive expression rate of endometrial tissue factor in the experiment B group （94.0%） was significantly higher than that in the experiment A group （22.0%） and the control group （14.0%）,P〈0.05 or P〈0.05. There was significant difference in the positive expression rate of endometrial tissue factor between the experiment A group and the control group （P〈0.05）. Conclusion The positive expression rate of tissue factor in proliferative ectopic endometrium tis-sue is more significant, the high expression of tissue factor has guidance function to specific judgement and targeted therapy for proliferative endometriosis.