1Peyromaure M, Debr6 B, Mao K, et al. Management of prostate cancer in China: a multicenter report of 6 institutions [ J ]. J Urol, 2005,174 (5) : 1794 - 1797.
3laffoul J J, Sarkar FH, Hillman GG. Radiosensitization of prostate cancer by soy isoflavones [ Jl. Curr Cancer Drug Targets, 2007,7 (8) :759 -765.
4Sasaki R, Shirakawa T, Zhang Z J, et al. Additional gene therapy with AdSCMV - p53 enhanced the efficacy of radiotherapy in hu- man prostate cancer cells [J]. Int J Radiat Oncol Biol Phys, 2001,51 (5) :1336 - 1345.
5Cowen D, Salem N, Ashoori F, et al. Prostate cancer radiosensiti- zation in vivo with adenovirus - mediated p53 gene therapy [ J ]. Clin Cancer Res, 2000,6 ( 11 ) :4402 - 4408.
6Watanabe T, Ichikawa A, Saito H, et al. Overexpression of the MDM2 oncogene in leukemia and lym~homa [ J] . Leuk Lympho- ma, 1996,21 (5-6) :391-397.
7Freedman DA, Wu L, Levine AJ. Functions of the MDM2 oncop- rotein[ J ] . CellMol Life Sci, 1999, 55 (1) :96 - 107.
8Juven -Gershon T, Oren M. MDM2: the ups and downs[ J]. Mol Meal,1999,5 (2) :71 -83.
10Bianco R, Ciardiello F, Tortora G. Cherhosensitization by anti- sense oligonucleotides targeting MDM2 [ J 1. Curt Cancer Drug Targets ,2005,5(1) :51 -56.
2Quanz M,Sun JS,Dutreix M,et al.Small molecule drugs mimicking DNA damage:a new strategy for sensitizing tumors to radiotherapy.Clin Cancer Res,2009,15:1308-1316.
3Quanz M,Chassoux D,Dutreix M,et al.Hyperativation of DNAPK by double-strand break minicking molecules disorganizes DNA damage response.PLOS One,2009,4:6298.
4Pang D,Yoo S,Dynan S,et al.Ko proteins join DNA fragments as shown by atomic force microscopy.Cancer Res,1997,57:1412-1415.
5Yoo S,Kimzey A,Dynan W.Photocross-linking of an oriented DNA repair complex.Ku bound at a single DNA end.J Biol Chem,1999,274:20034-20039.
6Walker JR,Corpina RA,Goldberg J.Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.Nature,2001,412:607-614.
7Nimura Y,Ismail SM,Kurimas L,et al.DNA-PK and ATM are required for radiation enhanced integration.Radiat Res,2002,157:562-567.
8Helleday T,Petermann E,Lundin C,et al.DNA repair pathways as targets for cancer therapy.Nat Rev Cancer,2008,624:162-178.
9Sun JS,Cosset JM,Dutreix M.Gamma H2AX foei disorganization by trapping DNA-PK with a double strand break mimicking agent:a radio-sensitizing method.AACR Meeting Abstract[2009-02-10].http://www.dna-therapeutics.com/doc/File/pdf/ AACR2K7.pdf.
10Fernandez O,Celeste A,Nussenzweig A.Focusing on foci:H2AX and the recruit-ment of DNA damage response factors.Cell Cycle,2003,2:426-427.
