核苷酸类抗病毒药物治疗对乙型病毒性肝炎肝硬化患者HBV-DNA及HBeAg转阴率的影响

Nucleotide Antiviral Therapy Effects of HBV-DNA and HBe Ag in Patients with liver Cirrhosis After Hepatitis B Virus Rate of

目的探讨常规+核苷类抗病毒药物在乙型病毒性肝炎肝硬化患者中的应用价值及其对乙型肝炎病毒脱氧核糖核酸(HBV-DNA)水平、乙型病毒性肝炎e抗原(HBe Ag)转阴率的影响。方法将我院104例乙型肝炎肝硬化患者以随机数字表法分为观察组与对照组,对照组患者行常规治疗,观察组患者对症治疗基础上给予核苷酸类抗病毒药物,比较两组患者的HBV-DNA降幅,HBe Ag转阴率。结果观察组HBV-DNA降低幅度为(5.33±2.34)lg拷贝/ml,明显高于对照组(0.56±0.17)lg拷贝/ml(P<0.05);观察组HBV-DNA转阴率明显较高(P<0.05);观察组HBe Ag转阴率明显较高(P<0.05)。结论常规+核苷酸类抗病毒药物治疗乙型病毒性肝炎肝硬化效果明显,可降低HBV-DNA水平,提高HBe Ag转阴率。

Objective To investigate the application value of conventional and antiviral drugs in patients with hepatitis B cirrhosis and its on hepatitis B virus（HBV）DNA（HBV-DNA）level,hepatitis B e antigen（HBeAg）negative conversion rate influence.Methods 104 cases of HBV patients with cirrhosis treated in our hospital were selected as the study objects.They are randomly divided into observation group and control group with each group 52 cases.Patients in the control group were given conventional treatment,while patients in the observation group were given symptomatic treatment combined with nucleotide antivirus drugs treatment.Compare both groups＇HBV-DNA decreasing amplitude and HBeAg negative conversion ratio.Results HBV-DNA in the observation group to reduce the magnitude of（5.33 ±2.34）1g copies/ml,significantly higher（0.56 ± 0.17）lg copies/ml （P〈 0.05）;HBV-DNA negativeobservation group was significantly higher（P〈0.05）;observation group HBeAg seroconversion rate was significantly higher（P〈0.05）.Conlusion Conventional＋nucleotide antiviral treatment effect is obvious cirrhosis,can reduce HBV-DNA leveI,HBeAg seroconversion rate increase.