组合型人工肾对尿毒症患者甲状旁腺素清除效果的影响

Effect of Combined type Artificial Kidney in Uremia Patients with Parathyroid Hormone Removal

目的探讨组合型人工肾(血液灌流联合血液透析)清除尿毒症患者血清甲状旁腺激素(PTH)的效果。方法将66例进行维持性血液透析的尿毒症患者分为两组,A组为单纯血液透析组(HD),B组为血液灌流联合血液透析组(HP+HD)。观察两组患者每次治疗前后血清PTH的变化情况。结果 A组患者治疗前后血清PTH变化不明显,差异无统计学意义(P>0.05);B组患者治疗前后PTH变化大,治疗后血清PTH下降明显,差异有统计学意义(P<0.05)。但B组患者治疗后PTH水平明显优于A组,差异有统计学意义(P<0.05)。结论血液灌流联合血液透析可有效清除血清中的甲状旁腺激素,对提高和改善尿毒症患者的生存期及生活质量具有重要意义。

Objective To evaluate the clear efficiency of serum Parathyroid Hormone（PTH）by HD＋HP （hematodialysis and hemoperfusion）.Methods Divide 66 patients with uremia into two groups,A group were treated by HD only and B group were treated by HP＋HD.Measure the change of PTH in serum respectively.Results The PTH was the same before and after the treatment of group A（P〉0.05）,while that decrease after the treatment of group B（P〈0.05）. But the B group patients after PTH was better than that of A group,the difference was statistically significant（P〈 0.05）. Conclusion The treatment of HD＋HP could decrease the serum PTH efficiently, which is important for the therapeutic effect of uremia patients.