纤维支气管镜肺泡灌洗治疗支气管扩张合并感染的疗效

Effect of Fiberoptic Bronchoscopy Alveolar Lavage on the Treatment of Bronchiectasis with Infection and Serum TNF-α and Hs-CRP Levels

目的分析纤维支气管镜肺泡灌洗治疗支气管扩张合并感染的疗效及对血清TNF-α和hs-CRP含量的影响。方法选择在该院接受住院治疗的支气管扩张合并感染患者作为研究对象,随机分为接受常规治疗的对照组以及接受纤维支气管镜肺泡灌洗治疗的观察组,比较两组患者的临床症状缓解时间,血清TNF-α和hs-CRP水平与血气水平等差异。结果观察组患者接受纤维支气管镜肺泡灌洗治疗后的发热、咳嗽咳痰及肺部湿啰音等症状体征缓解时间明显短于对照组患者(P<0.05)。观察组患者接受治疗后的血清TNF-α和hs-CRP水平值明显低于对照组患者(P<0.05)。观察组患者治疗后的Pa O2和Pa O2/Fi O2水平高于对照组;Pa CO2水平低于对照组患者(P<0.05)。结论纤维支气管镜肺泡灌洗治疗可以促进支气管扩张合并感染患者的早期康复,优化血清炎症因子水平,改善有效通气状态。

[ Objective ] To analyze the effect of fiberoptic bronchoscopy alveolar lavage on the treatment of bronchiectasis with infection and serum TNF-a and hs-CRP levels. [Methods] Patients with bronchiectasis com bined infection in our hospital were chosen as research objects, randomly divided into control group with conventional treatment and observation group with fiberoptic bronchoscopy alveolar lavage. The clinical symptoms time, serum TNF-a, hs-CRP levels and blood gas levels in two groups were compared. [Results] The relieved time of symptom of fever, cough and expectoration, and other signs in observation group were significantly shorter than that in control group （P 〈0.05）. The patients serum TNF-a and hs-CRP levels in observation group were significantly lower （P 〈 0.05）. The patients＇ PaO2, PaO2/FiO2 levels were higher, while PaCO2 level was lower （P 〈0.05）. [Conclusion] The treatment of fiberoptic bronchoscopy alveolar lavage can contribute to the early rehabilitation of patients with bronchiectasis with infection, optimize the serum levels of inflammatory factors and improve the effective ventilation state.